Evidence map›Paper›PMID 20211596›Full record

ReviewBiochimica et biophysica acta

The regulation and turnover of mitochondrial uncoupling proteins.

Vian Azzu, Martin Jastroch, Ajit S Divakaruni, Martin D Brand

Abstract readReview
In one paragraph

Review in Biochimica et biophysica acta. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 143 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Antioxidants (Basel, Switzerland) · 2024
    Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Coevolution of body size and metabolic rate in vertebrates: a life-history perspective.Biological reviews of the Cambridge Philosophical Society · 2020
    Article
  18. Article
  19. Article
  20. Journal of the Endocrine Society · 2020
    Article

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Vian AzzuMedical Research Council Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK. va@mrc-mbu.cam.ac.uk
Martin Jastroch
Ajit S Divakaruni
Martin D Brand
Buck Institute for Research on Aging · USMRC Mitochondrial Biology Unit · GB

Funding

PROTEOMICSP01AG025901 · NIA · BUCK INSTITUTE FOR RESEARCH ON AGING · PI GIBSON, BRADFORD WAYNE · 2007 to 2011
$8.6M
Mass spectrometry and imaging technologies in GerosciencePL1AG032118 · NIA · BUCK INSTITUTE FOR RESEARCH ON AGING · PI GIBSON, BRADFORD WAYNE · 2007 to 2011
$4.5M
Interdisciplinary Research Consortium in GeroscienceUL1DE019608 · NIDCR · BUCK INSTITUTE FOR RESEARCH ON AGING · PI LITHGOW, GORDON J · 2008 to 2011
$4.0M
Core--RESEARCH DEVELOPMENTP30AG025708 · NIA · BUCK INSTITUTE FOR RESEARCH ON AGING · PI CAMPISI, JUDITH · 2005 to 2009
$3.7M
Mitochondrial sites of reactive oxygen species generation in cells.R01AG033542 · NIA · BUCK INSTITUTE FOR RESEARCH ON AGING · PI BRAND, MARTIN D · 2009 to 2010
$970k
Medical Research Council MC_U105663137NIA NIH HHS P01 AG025901NIA NIH HHS P30 AG025708NIA NIH HHS PL1 AG032118NIA NIH HHS R01 AG033542NIDCR NIH HHS UL1 DE019608
6 · The paper itself

Abstract

Uncoupling proteins (UCP1, UCP2 and UCP3) are important in regulating cellular fuel metabolism and as attenuators of reactive oxygen species production through strong or mild uncoupling. The generic function and broad tissue distribution of the uncoupling protein family means that they are increasingly implicated in a range of pathophysiological processes including obesity, insulin resistance and diabetes mellitus, neurodegeneration, cardiovascular disease, immunity and cancer. The significant recent progress describing the turnover of novel uncoupling proteins, as well as current views on the physiological roles and regulation of UCPs, is outlined.

Indexed as

AnimalsDiabetes MellitusEnergy MetabolismGene ExpressionHumansInsulin ResistanceIon ChannelsMitochondriaMitochondrial ProteinsModels, BiologicalObesityUncoupling Protein 1Uncoupling Protein 2Uncoupling Protein 3Ion ChannelsMitochondrial ProteinsUCP1 protein, humanUCP2 protein, humanUCP3 protein, humanUncoupling Protein 1Uncoupling Protein 2Uncoupling Protein 3

Identifiers

PMID20211596
PMCPMC2891119
OpenAlexW2070728564

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.