ArticleNeurobiology of disease2010
NPY mediates ATP-induced neuroproliferation in adult mouse olfactory epithelium.
Article in Neurobiology of disease, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 54 citations in OpenAlex.
- FAK inhibition following acute olfactory epithelial inflammation promotes neurogenesis and functional recovery through stem cell CNTF.Stem cells (Dayton, Ohio) · 2026Article
- A nasal cell atlas reveals heterogeneity of tuft cells and their role in directing olfactory stem cell proliferation.Science immunology · 2024Article
- Constitutive and evoked release of ATP in adult mouse olfactory epithelium.Open life sciences · 2024Article
- SARS-CoV-2 infection of sustentacular cells disrupts olfactory signaling pathways.JCI insight · 2022Article
- The nervous system during COVID-19: Caught in the crossfire.Immunological reviews · 2022Review
- Modulation of olfactory signal detection in the olfactory epithelium: focus on the internal and external environment, and the emerging role of the immune system.Cell and tissue research · 2021Review
- Diving into the streams and waves of constitutive and regenerative olfactory neurogenesis: insights from zebrafish.Cell and tissue research · 2021Review
- Alzheimer's Disease: What Can We Learn From the Peripheral Olfactory System?Frontiers in neuroscience · 2020Review
- TMEM16A calcium-activated chloride currents in supporting cells of the mouse olfactory epithelium.The Journal of general physiology · 2019Article
- Purinergic Signaling in the Vertebrate Olfactory System.Frontiers in cellular neuroscience · 2019Review
- Functional Reintegration of Sensory Neurons and Transitional Dendritic Reduction of Mitral/Tufted Cells during Injury-Induced Recovery of the LarvalFrontiers in cellular neuroscience · 2017Article
- Effects of Neuropeptide Y on Stem Cells and Their Potential Applications in Disease Therapy.Stem cells international · 2017Review
- Extracellular ATP and other nucleotides-ubiquitous triggers of intercellular messenger release.Purinergic signalling · 2016Review
- Cannabinoid receptor signaling induces proliferation but not neurogenesis in the mouse olfactory epithelium.Neurogenesis (Austin, Tex.) · 2016Article
- Primary Cilia on Horizontal Basal Cells Regulate Regeneration of the Olfactory Epithelium.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Translational potential of olfactory mucosa for the study of neuropsychiatric illness.Translational psychiatry · 2015Review
- Purinergic receptor-induced Ca2+ signaling in the neuroepithelium of the vomeronasal organ of larval Xenopus laevis.Purinergic signalling · 2014Article
- Molecular events in the cell types of the olfactory epithelium during adult neurogenesis.Molecular brain · 2013Article
- Peripheral modulation of smell: fact or fiction?Seminars in cell & developmental biology · 2013Review
- An IP3R3- and NPY-expressing microvillous cell mediates tissue homeostasis and regeneration in the mouse olfactory epithelium.PloS one · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In the CNS, ATP is released upon injury and promotes neuroproliferation via purinergic receptors. In the olfactory epithelium, ATP promotes the synthesis and release of neurotrophic factor NPY in neonates and induces neuroproliferation in neonatal and adult mice. We tested the hypothesis that NPY is involved in ATP-induced neuroproliferation in adult mice olfactory epithelium. Intranasal instillation of ATP significantly increased protein levels and number of NPY(+) cells. Pre-intranasal instillation of purinergic receptor antagonist PPADS significantly reduced ATP-induced upregulation of NPY. Intranasal instillation of NPY-Y1 receptor antagonist BIBP3226 following ATP instillation significantly inhibited the ATP-induced increase in BrdU incorporation, suggesting that NPY is released after ATP instillation and activates Y1 receptors to promote neuroproliferation. These data indicate that ATP initiates neuroproliferation via NPY upregulation, NPY release, and Y1 receptor activation, and suggests that the olfactory epithelium is good model to study neuroregenerative mechanisms in the CNS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.