ReviewBiochemical pharmacology2010
Striking the target in Wnt-y conditions: intervening in Wnt signaling during cancer progression.
Review in Biochemical pharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- The functional roles of the circRNA/Wnt axis in cancer.Molecular cancer · 2022Review
- Mechanism of Anti-Cancer Activity of Curcumin on Androgen-Dependent and Androgen-Independent Prostate Cancer.Nutrients · 2020Review
- Accelerating the Production of Druggable Targets: Eukaryotic Cell-Free Systems Come into Focus.Methods and protocols · 2019Article
- Wnt signaling in multiple myeloma: a central player in disease with therapeutic potential.Journal of hematology & oncology · 2018Review
- Wnt5a / planar cell polarity signaling pathway in urothelial carcinoma, a potential prognostic biomarker.Oncotarget · 2017Article
- AKT/GSK3β Signaling in Glioblastoma.Neurochemical research · 2017Review
- Molecular Signaling in Benign Odontogenic Neoplasia Pathogenesis.Current oral health reports · 2016Article
- Interleukin-6 drives melanoma cell motility through p38α-MAPK-dependent up-regulation of WNT5A expression.Molecular oncology · 2014Article
- Serum secreted frizzled-related protein 5 levels differentially decrease in patients with hepatitis B virus-associated chronic infection and hepatocellular carcinoma.Oncology letters · 2014Article
- Macrophages mediate a switch between canonical and non-canonical Wnt pathways in canine mammary tumors.PloS one · 2014Article
- Activation of the Wnt pathway through AR79, a GSK3β inhibitor, promotes prostate cancer growth in soft tissue and bone.Molecular cancer research : MCR · 2013Article
- Human placental trophoblast invasion and differentiation: a particular focus on Wnt signaling.Frontiers in genetics · 2013Review
- Lung cancer stem cells: progress and prospects.Cancer letters · 2013Review
- Wnt signaling in the pathogenesis of human HIV-associated pain syndromes.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2013Article
- Article
- MiR-590-5P inhibits growth of HepG2 cells via decrease of S100A10 expression and Inhibition of the Wnt pathway.International journal of molecular sciences · 2013Article
- GSK3β inhibition blocks melanoma cell/host interactions by downregulating N-cadherin expression and decreasing FAK phosphorylation.The Journal of investigative dermatology · 2012Article
- Toward rational fragment-based lead design without 3D structures.Journal of medicinal chemistry · 2012Article
- Regulation of Wnt signaling by nociceptive input in animal models.Molecular pain · 2012Article
- Frizzled7 as an emerging target for cancer therapy.Cellular signalling · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Wnt signaling can be divided into three pathways, namely the canonical Wnt/beta-catenin pathway, and the non-canonical (or heretical) Wnt/Ca(2+) and planar cell polarity (PCP) pathways. Although the canonical Wnt/beta-catenin pathway is the best described in cancer, increasing data points to the importance of the heretical Wnt pathways in several aspects of tumor progression. The recent advances in understanding the players and mechanisms by which these Wnt pathways contribute to cancer progression have led to the identification of numerous molecules that are already, or could be considered, targets for cancer therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.