Evidence map›Paper›PMID 20211101›Full record

ArticleJournal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale2010

Optical coherence tomography of the larynx using the Niris system.

Marc Rubinstein, Esther L Fine, Ali Sepehr, William B Armstrong, Roger L Crumley, Jason H Kim, Zhongping Chen, Brian J F Wong

Open access · greenAbstract readComparative Study
PubMed Full text at PMC
In one paragraph

Article in Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Marc RubinsteinDepartment of Otolaryngology--Head and Neck Surgery and Beckman Laser Institute and Medical Clinic, University of California Irvine, Irvine, California, USA.
Esther L Fine
Ali Sepehr
William B Armstrong
Roger L Crumley
Jason H Kim
Zhongping Chen
Brian J F Wong
University of California, Irvine · US

Funding

ZOVIRAX CREAM TO TREAT HERPES LABIALIS IN ADOLESCENTSM01RR000827 · NCRR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHANG, R JEFFREY · 1985 to 2010
$74.3M
Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Christine Hui · 1994 to 2026
$57.9M
WOUND MIGRATION FORCE MONITORINGP41RR001192 · NCRR · UNIVERSITY OF CALIFORNIA-IRVINE · PI LYUBOVITSKY, JULIA · 1985 to 2011
$14.2M
Optical Biopsy Using MEMs TechnologyR01CA091717 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, ZHONGPING · 2002 to 2006
$2.9M
Integrated multi-modality intravascular US/OCT imaging systemR01EB010090 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, ZHONGPING · 2009 to 2012
$2.3M
HIGH SPEED HIGH RESOLUTION PHASE RESOLVED OCT/ODTR01EB000293 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, ZHONGPING · 2002 to 2009
$1.9M
NonInvasive Optical Imaging of Vocal Cord MicrostructureR21DC006026 · NIDCD · UNIVERSITY OF CALIFORNIA IRVINE · PI WONG, BRIAN · 2003 to 2004
$301k
NCI NIH HHS CA 91717NCI NIH HHS P30 CA062203NCI NIH HHS R01 CA091717NCRR NIH HHS M01 RR000827NCRR NIH HHS P41 RR001192NCRR NIH HHS RR00827NCRR NIH HHS RR 01192NIBIB NIH HHS EB 00293NIBIB NIH HHS R01 EB000293NIBIB NIH HHS R01 EB010090NIDCD NIH HHS DC 006026NIDCD NIH HHS R21 DC006026
6 · The paper itself

Abstract

objectivesTo present our experience using the first commercially available optical coherence tomography (OCT) device for use in the head, neck, and upper aerodigestive tract and to determine the feasibility and efficacy of this system in comparison with our previous experience using other research OCT systems.

methodsUsing the Niris OCT imaging system (Imalux, Cleveland, OH), we obtained OCT images of benign and premalignant laryngeal disease in 33 patients undergoing surgical head and neck endoscopy. This imaging system has a spatial depth resolution of 10 to 20 mum and a depth scanning range of 2.2 mm, obtaining images of 200 x 200 pixels at a maximum frame rate of 0.7 Hz. The scanning mechanism of the device is located at the distal end of a flexible probe that is placed in contact or near-contact with the area of interest. The tip of the probe was inserted through a rigid laryngoscope, and still images were obtained.

resultsOCT images of arytenoids, aryepiglottic folds, piriform sinus, epiglottis, and true and false vocal cords were obtained. In patients whose OCT images were taken from normal tissue, the normal microstructures were clearly identified, as well as disruption of the latter in malignant pathologies.

conclusionsThe device can easily be incorporated into the operating room and requires minimal set-up and staff to operate. OCT imaging with this device potentially offers an efficient, quick, and reliable imaging modality in guiding surgical biopsies, intraoperative decision making, and therapeutic options of various laryngeal pathologies and premalignant disease.

Indexed as

AdolescentAdultAgedAged, 80 and overEndoscopy, GastrointestinalFeasibility StudiesFemaleHumansLaryngeal DiseasesLarynxMaleMiddle AgedTomography, Optical Coherence

Identifiers

PMID20211101
PMCPMC2898737
OpenAlexW2160101258

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.