Evidence map›Paper›PMID 20210782›Full record

ReviewCurrent HIV research2010

Feline immunodeficiency virus (FIV) as a model for study of lentivirus infections: parallels with HIV.

John H Elder, Ying-Chuan Lin, Elizabeth Fink, Chris K Grant

Abstract readReview
In one paragraph

Review in Current HIV research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed.

  1. Article
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  9. Review
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

John H ElderDepartment of Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla, CA 92037, USA. jelder@scripps.edu
Ying-Chuan Lin
Elizabeth Fink
Chris K Grant

Funding

MOLECULAR CHARACTERIZATION OF FIVR01AI025825 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI ELDER, JOHN H · 1987 to 2015
$6.0M
Substrate/Inhibitor Specificity of FIV and HIV PRsR01AI040882 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI ELDER, JOHN H · 1997 to 2006
$1.6M
NIAID NIH HHS R01 AI025825NIAID NIH HHS R01AI025825NIAID NIH HHS R01 AI040882NIAID NIH HHS R01AI040882
6 · The paper itself

Abstract

FIV is a significant pathogen in the cat and is, in addition, the smallest available natural model for the study of lentivirus infections. Although divergent at the amino acid level, the cat lentivirus has an abundance of structural and pathophysiological commonalities with HIV and thus serves well as a model for development of intervention strategies relevant to infection in both cats and man. The following review highlights both the strengths and shortcomings of the FIV/cat model, particular as regards development of antiviral drugs.

Indexed as

Disease Models, AnimalImmunodeficiency Virus, FelineAnimalsAspartic Acid ProteasesCatsDrug DesignFeline Acquired Immunodeficiency SyndromeGene Products, gagGene Products, polHIVHIV InfectionsHumansProtease InhibitorsVirus ReplicationAspartic Acid ProteasesGene Products, gagGene Products, polProtease Inhibitors

Identifiers

PMID20210782
PMCPMC2853889

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.