Evidence map›Paper›PMID 20210556›Full record

ReviewFuture microbiology2010

Human immune responses in cryptosporidiosis.

Anoli Borad, Honorine Ward

Open access · greenAbstract readReview
In one paragraph

Review in Future microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 103 citations in OpenAlex.

  1. Article
  2. Review
  3. Efficacy of nitazoxanide, ivermectin and albendazole in treatment of cryptosporidiosis in immunosuppressed mice.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2025
    Article
  4. Review
  5. Review
  6. Article
  7. Ubiquitination of Immune System and Cancer Therapy.Advances in experimental medicine and biology · 2024
    Review
  8. Review
  9. Use of nanoparticles, a modern means of drug delivery, against cryptosporidiosis.Journal of advanced veterinary and animal research · 2023
    Review
  10. Evaluation of the therapeutic efficacy of some essential oils in experimentally immunosuppressed mice infected withJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2023
    Article
  11. Article
  12. Review
  13. Dendritic Cells andMicroorganisms · 2023
    Review
  14. Article
  15. C3a/C3aR Affects the Propagation ofAnimals : an open access journal from MDPI · 2023
    Article
  16. Review
  17. Review
  18. Asymptomatic Cryptosporidiosis in Children Living with HIV.Tropical medicine and infectious disease · 2022
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Anoli BoradDivision of Internal Medicine, Section of Infectious Diseases, Yale University, 300 Cedar Street, TAC S169, New Haven, CT 06520, USA. anoli.borad@yale.edu
Honorine Ward
Tufts Medical Center · USYale University · US

Funding

Immune Response to Cryptosporidiosis in a Birth Cohorot of Children of South IndiR01AI072222 · NIAID · TUFTS MEDICAL CENTER · PI WARD, HONORINE D · 2008 to 2012
$3.1M
NEMCH CLINICAL RESEARCH ON AIDS TRAINING GRANTT32AI007438 · NIAID · TUFTS MEDICAL CENTER · PI WANKE, CHRISTINE A · 1992 to 2012
$2.5M
NIAID NIH HHS NIH T32AI07438NIAID NIH HHS R01 AI072222NIAID NIH HHS T32 AI007438
6 · The paper itself

Abstract

Immune responses play a critical role in protection from, and resolution of, cryptosporidiosis. However, the nature of these responses, particularly in humans, is not completely understood. Both innate and adaptive immune responses are important. Innate immune responses may be mediated by Toll-like receptor pathways, antimicrobial peptides, prostaglandins, mannose-binding lectin, cytokines and chemokines. Cell-mediated responses, particularly those involving CD4(+) T cells and IFN-gamma play a dominant role. Mucosal antibody responses may also be involved. Proteins mediating attachment and invasion may serve as putative protective antigens. Further knowledge of human immune responses in cryptosporidiosis is essential in order to develop targeted prophylactic and therapeutic interventions. This review focuses on recent advances and future prospects in the understanding of human immune responses to Cryptosporidium infection.

Indexed as

Adaptive ImmunityImmunity, InnateAnimalsCryptosporidiosisCryptosporidiumHumansImmunity, CellularImmunity, MucosalProtozoan VaccinesProtozoan Vaccines

Identifiers

PMID20210556
PMCPMC2856646
OpenAlexW2090258240

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.