ArticleStatistics in medicine2010
Proportional hazards models and age-period-cohort analysis of cancer rates.
Article in Statistics in medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed.
- Gastric cancer incidence among Hispanics in California: patterns by time, nativity, and neighborhood characteristics.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2012Trial
- Global, Regional, and National Burden of Heart Failure Attributable to Chronic Obstructive Pulmonary Disease From 1990 to 2021, With Projections to 2050.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2026Article
- Trend Dynamics of Rheumatic Heart Disease Burden, 1990-2019: Insights From Age-Period-Cohort Modeling and Projections.Reviews in cardiovascular medicine · 2026Article
- Global trends in cardiovascular mortality attributable to high body mass index: 1990-2021 analysis with future projections.American journal of preventive cardiology · 2025Article
- Global Burden of Chronic Obstructive Pulmonary Disease and Heart Failure Comorbidity in Older Adults: An Analysis of the Global Burden of Disease Study.Aging and disease · 2025Article
- Burden and risk factors of premature drowning mortality in 204 countries and territories, 1980-2021.Scientific reports · 2025Article
- The Challenge in Burden of Pulmonary Arterial Hypertension: A Perspective From the Global Burden of Disease Study.MedComm · 2025Article
- Global Trends in Ischemic Heart Disease Mortality from 1990 to 2021 and 2036 Projections: Insights from GBD 2021 Data.Global heart · 2025Article
- Global, regional, and national time trends in the burden of epilepsy, 1990-2019: an age-period-cohort analysis for the global burden of disease 2019 study.Frontiers in neurology · 2024Article
- Trends in breast cancer mortality attributable to metabolic risks in Chinese women from 1990 to 2019: an age-period-cohort analysis.Frontiers in oncology · 2024Article
- Global, Regional, and National Change Patterns in the Incidence of Low Back Pain From 1990 to 2019 and Its Predicted Level in the Next Decade.International journal of public health · 2024Article
- Global, regional, and national temporal trends in mortality and disability-adjusted life years for cardiovascular disease attributable to low temperature during 1990-2019: an age-period-cohort analysis of the global burden of disease 2019 study.Frontiers in public health · 2024Article
- Comparative age-period-cohort analysis.BMC medical research methodology · 2023Article
- Smoothing Lexis diagrams using kernel functions: A contemporary approach.Statistical methods in medical research · 2023Article
- Article
- Global, regional, and national time trends in disability-adjusted life years, mortality, and variable risk factors of non-rheumatic calcified aortic valve disease, 1990-2019: an age-period-cohort analysis of the Global Burden of Disease 2019 study.Journal of thoracic disease · 2023Article
- Time Trends in Ischemic Heart Disease Mortality Attributable to PMInternational journal of environmental research and public health · 2023Article
- Study on the burden of digestive diseases among Chinese residents in the 21st century.Frontiers in public health · 2023Article
- Epidemiological trend and age-period-cohort effects on cardiovascular disease mortality and disability-adjusted life years attributable to dietary risks and high body mass index at the regional and country level across China and Pakistan.Frontiers in nutrition · 2023Article
- Burden of falls attributable to low bone mineral density among people aged 60 years and over in China from 1990 to 2019.Frontiers in public health · 2023Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Age-period-cohort (APC) analysis is widely used in cancer epidemiology to model trends in cancer rates. We develop methods for comparative APC analysis of two independent cause-specific hazard rates assuming that an APC model holds for each one. We construct linear hypothesis tests to determine whether the two hazards are absolutely proportional or proportional after stratification by cohort, period, or age. When a given proportional hazards model appears adequate, we derive simple expressions for the relative hazards using identifiable APC parameters. To demonstrate the utility of these new methods, we analyze cancer incidence rates in the United States in blacks versus whites for selected cancers, using data from the National Cancer Institute's Surveillance, Epidemiology, and End Results Program. The examples illustrate that each type of proportionality may be encountered in practice.
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