ArticlePloS one2010
Periodic table of virus capsids: implications for natural selection and design.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Review
- Cryo-EM resolves the structure of the archaeal dsDNA virus HFTV1 from head to tail.Science advances · 2025Article
- Stabilization mechanism accommodating genome length variation in evolutionarily related viral capsids.Nature communications · 2025Article
- Explicit description of viral capsid subunit shapes by unfolding dihedrons.Communications biology · 2024Article
- Modeling reveals the strength of weak interactions in stacked-ring assembly.Biophysical journal · 2024Article
- Cryo-EM structure of ssDNA bacteriophage ΦCjT23 provides insight into early virus evolution.Nature communications · 2022Article
- A Capsid Structure ofViruses · 2022Article
- Viral Phrenology.Viruses · 2021Article
- Minimal Design Principles for Icosahedral Virus Capsids.ACS nano · 2021Article
- Large-Scale Molecular Dynamics Simulations of Cellular Compartments.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Surface stresses in complex viral capsids and non-quasi-equivalent viral architectures.Journal of the Royal Society, Interface · 2020Article
- Principles for enhancing virus capsid capacity and stability from a thermophilic virus capsid structure.Nature communications · 2019Article
- A Multiscale Model for the Self-Assembly of Coat Proteins in Bacteriophage MS2.Journal of chemical information and modeling · 2019Article
- Cryo-EM structure and in vitro DNA packaging of a thermophilic virus with supersized T=7 capsids.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Electrostatics-Driven Inflation of Elastic Icosahedral Shells as a Model for Swelling of Viruses.Biophysical journal · 2018Article
- Chiral symmetry breaking yields the I-AuNature communications · 2018Article
- Viral Capsid Assembly: A Quantified Uncertainty Approach.Journal of computational biology : a journal of computational molecular cell biology · 2018Article
- Multimerization rules for G-quadruplexes.Nucleic acids research · 2017Article
- AChiralPentagonalPolyhedralFramework forCharacterizingVirusCapsidStructures.Trends in microbiology · 2017Review
- Uncertainty Quantified Computational Analysis of the Energetics of Virus Capsid Assembly.Proceedings. IEEE International Conference on Bioinformatics and Biomedicine · 2016Article
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2 authors.
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Abstract
backgroundFor survival, most natural viruses depend upon the existence of spherical capsids: protective shells of various sizes composed of protein subunits. So far, general evolutionary pressures shaping capsid design have remained elusive, even though an understanding of such properties may help in rationally impeding the virus life cycle and designing efficient nano-assemblies. PRINCIPAL
findingsThis report uncovers an unprecedented and species-independent evolutionary pressure on virus capsids, based on the the notion that the simplest capsid designs (or those capsids with the lowest "hexamer complexity", C(h)) are the fittest, which was shown to be true for all available virus capsids. The theories result in a physically meaningful periodic table of virus capsids that uncovers strong and overarching evolutionary pressures, while also offering geometric explanations to other capsid properties (rigidity, pleomorphy, auxiliary requirements, etc.) that were previously considered to be unrelatable properties of the individual virus. SIGNIFICANCE: Apart from describing a universal rule for virus capsid evolution, our work (especially the periodic table) provides a language with which highly diverse virus capsids, unified only by geometry, may be described and related to each other. Finally, the available virus structure databases and other published data reiterate the predicted geometry-derived rules, reinforcing the role of geometry in the natural selection and design of virus capsids.
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