ArticlePloS one2010
Increasing alternative promoter repertories is positively associated with differential expression and disease susceptibility.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
- A Genome-Wide Investigation of Effects of Aberrant DNA Methylation on the Usage of Alternative Promoters in Hepatocellular Carcinoma.Frontiers in oncology · 2021Article
- So close, no matter how far: multiple paths connecting transcription to mRNA translation in eukaryotes.EMBO reports · 2020Review
- Transcriptional Complexity and Distinct Expression Patterns ofG3 (Bethesda, Md.) · 2017Article
- Alternate promoter usage generates two subpopulations of the neuronal RhoGEF Kalirin-7.Journal of neurochemistry · 2017Article
- RNA-sequence analysis of gene expression from honeybees (Apis mellifera) infected with Nosema ceranae.PloS one · 2017Article
- Epigenetic basis of regeneration: analysis of genomic DNA methylation profiles in the MRL/MpJ mouse.DNA research : an international journal for rapid publication of reports on genes and genomes · 2013Article
- Differential regulation of the mouse and human Wnt5a alternative promoters A and B.DNA and cell biology · 2012Article
- Strategies to explore functional genomics data sets in NCBI's GEO database.Methods in molecular biology (Clifton, N.J.) · 2012Article
- Genome-wide approaches for cancer gene discovery.Trends in biotechnology · 2011Review
- CCAAT/enhancer binding protein-beta negatively regulates the expression of glycerol-3-phosphate dehydrogenase 1 in pig PK-15 cells.Journal of applied genetics · 2011Article
- Altered expression of Ano1 variants in human diabetic gastroparesis.The Journal of biological chemistry · 2011Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlternative Promoter (AP) usages have been shown to enable diversified transcriptional regulation of individual gene in a context-specific (e.g., pathway, cell lineage, tissue type, and development stage et. ac.) way. Aberrant uses of APs have been directly linked to mechanism of certain human diseases. However, whether or not there exists a general link between a gene's AP repertoire and its expression diversity is currently unknown. The general relation between a gene's AP repertoire and its disease susceptibility also remains largely unexplored. METHODOLOGY/PRINCIPAL
findingsBased on the differential expression ratio inferred from all human microarray data in NCBI GEO and the list of disease genes curated in public repositories, we systemically analyzed the general relation of AP repertoire with expression diversity and disease susceptibility. We found that genes with APs are more likely to be differentially expressed and/or disease associated than those with Single Promoter (SP), and genes with more APs are more likely differentially expressed and disease susceptible than those with less APs. Further analysis showed that genes with increased number of APs tend to have increased length in all aspects of gene structure including 3' UTR, be associated with increased duplicability, and have increased connectivity in protein-protein interaction network.
conclusionsOur genome-wide analysis provided evidences that increasing alternative promoter repertories is positively associated with differential expression and disease susceptibility.
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