ArticlePloS one2010
The Anopheles gambiae odorant binding protein 1 (AgamOBP1) mediates indole recognition in the antennae of female mosquitoes.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers.
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Who cites it
109 citing papers in PubMed.
- GravidInsects · 2026Article
- Functional characterization of AsOBP21f, an odorant-binding protein involved in human odor detection in the malaria vector Anopheles sinensis.Parasites & vectors · 2026Article
- Pleiotropic Function of Antenna-Specific Odorant-Binding Protein Links Xenobiotic Adaptation and Olfaction inInsects · 2025Article
- AgamOBP1-Directed Discovery of Repellents to Control the Spread of Mosquito-Borne Diseases.ChemMedChem · 2025Article
- Characterization of odorant binding and chemosensory protein families in the kissing bug Triatoma infestans: comparative analysis among Heteroptera species.BMC genomics · 2025Article
- Smelly communication between haemaphysalis longicornis and infected hosts with indolic odorants: A case from severe fever with thrombocytopenia syndrome virus.PLoS neglected tropical diseases · 2025Article
- UnravelingFrontiers in pharmacology · 2025Review
- Involvement of a Microplusin-like Gene (HlonML-1) in the Olfactory Chemosensation ofMicroorganisms · 2024Article
- Specialized structure and function of the apical extracellular matrix at sense organs.Cells & development · 2024Review
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- Roles of insect odorant binding proteins in communication and xenobiotic adaptation.Frontiers in insect science · 2023Review
- Article
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- Screening of olfactory genes related to blood-feeding behaviors in Culex pipiens quinquefasciatus and Culex pipiens molestus by transcriptome analysis.PLoS neglected tropical diseases · 2022Article
- Transcriptome analysis ofFrontiers in physiology · 2022Article
- The Odorant Binding Protein, SiOBP5, Mediates Alarm Pheromone Olfactory Recognition in the Red Imported Fire Ant,Biomolecules · 2021Article
- Mutually Exclusive Expression of Closely Related Odorant-Binding Proteins 9A and 9B in the Antenna of the Red Flour BeetleBiomolecules · 2021Article
- A new non-classical fold of varroa odorant-binding proteins reveals a wide open internal cavity.Scientific reports · 2021Article
- Antennal Enriched Odorant Binding Proteins Are Required for Odor Communication inBiomolecules · 2021Article
49 more citing papers are in PubMed but not listed here.
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14 authors.
Funding
Abstract
Haematophagous insects are frequently carriers of parasitic diseases, including malaria. The mosquito Anopheles gambiae is the major vector of malaria in sub-Saharan Africa and is thus responsible for thousands of deaths daily. Although the role of olfaction in A. gambiae host detection has been demonstrated, little is known about the combinations of ligands and odorant binding proteins (OBPs) that can produce specific odor-related responses in vivo. We identified a ligand, indole, for an A. gambiae odorant binding protein, AgamOBP1, modeled the interaction in silico and confirmed the interaction using biochemical assays. RNAi-mediated gene silencing coupled with electrophysiological analyses confirmed that AgamOBP1 binds indole in A. gambiae and that the antennal receptor cells do not respond to indole in the absence of AgamOBP1. This case represents the first documented instance of a specific A. gambiae OBP-ligand pairing combination, demonstrates the significance of OBPs in odor recognition, and can be expanded to the identification of other ligands for OBPs of Anopheles and other medically important insects.
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