ArticleNature nanotechnology2010
Detection of single-molecule H2O2 signalling from epidermal growth factor receptor using fluorescent single-walled carbon nanotubes.
Article in Nature nanotechnology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 257 citations in OpenAlex.
- Fluorescent Nanosensor for Indole-3-Propionic Acid Detection in Gut Health Monitoring.Advanced healthcare materials · 2026Article
- Aptamer-Functionalized SWCNT Optical Sensors for Selective and Robust Dopamine Detection in Physiological Media.ACS applied nano materials · 2026Article
- Selective and robust dopamine detection is enabled by aptamer-SWCNT optical sensors in physiological media.bioRxiv : the preprint server for biology · 2026Article
- Label-free and real-time monitoring of photoaging with high spatiotemporal resolution using an nIR fluorescent nanosensor array.Science advances · 2025Article
- Article
- Controlled Quantum Well Formation on DNA-Wrapped Carbon Nanotubes via Peroxide-Mediated Aryl Diazonium Reduction.Nano letters · 2025Article
- Development and Evaluation of an Expedited System for Creation of Single Walled Carbon Nanotube Platforms.Carbon letters · 2024Article
- Carbon Nanomaterial Fluorescent Probes and Their Biological Applications.Chemical reviews · 2024Review
- Real-timeBiomedical optics express · 2023Article
- Micro-engineering and nano-engineering approaches to investigate tumour ecosystems.Nature reviews. Cancer · 2023Review
- Polyoxometalate-based nanocomposites for antitumor and antibacterial applications.Nanoscale advances · 2022Review
- Small-Molecule Fluorescent Probes for Detecting Several Abnormally Expressed Substances in Tumors.Micromachines · 2022Review
- Biosensing with Fluorescent Carbon Nanotubes.Angewandte Chemie (International ed. in English) · 2022Review
- Anderson polyoxometalates with intrinsic oxidase-mimic activity for "turn on" fluorescence sensing of dopamine.Analytical and bioanalytical chemistry · 2021Article
- Nanophotonic biosensors harnessing van der Waals materials.Nature communications · 2021Review
- Cellular lensing and near infrared fluorescent nanosensor arrays to enable chemical efflux cytometry.Nature communications · 2021Article
- Carbon Nanomaterials: Synthesis, Functionalization and Sensing Applications.Nanomaterials (Basel, Switzerland) · 2021Review
- A Long-Term Stable Sensor Based on Fe@PCN-224 for Rapid and Quantitative Detection of HFoods (Basel, Switzerland) · 2021Article
- Single-Walled Carbon Nanotube Sensor Platform for the Study of Extracellular Analytes.ACS applied nano materials · 2021Article
- A synthetic mimic of phosphodiesterase type 5 based on corona phase molecular recognition of single-walled carbon nanotubes.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
An emerging concept in cell signalling is the natural role of reactive oxygen species such as hydrogen peroxide (H2O2) as beneficial messengers in redox signalling pathways. The nature of H2O2 signalling is confounded, however, by difficulties in tracking it in living systems, both spatially and temporally, at low concentrations. Here, we develop an array of fluorescent single-walled carbon nanotubes that can selectively record, in real time, the discrete, stochastic quenching events that occur as H2O2 molecules are emitted from individual human epidermal carcinoma cells stimulated by epidermal growth factor. We show mathematically that such arrays can distinguish between molecules originating locally on the cell membrane from other contributions. We find that epidermal growth factor induces 2 nmol H2O2 locally over a period of 50 min. This platform promises a new approach to understanding the signalling of reactive oxygen species at the cellular level.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.