ArticleNature neuroscience2010
Methylphenidate facilitates learning-induced amygdala plasticity.
Article in Nature neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 91 citations in OpenAlex.
- The synergy of methylphenidate- and reconsolidation-based extinction normalizes ventromedial prefrontal function in drug addiction.Proceedings of the National Academy of Sciences of the United States of America · 2025Trial
- Acetylcholine and noradrenaline enhance foraging optimality in humans.Proceedings of the National Academy of Sciences of the United States of America · 2023Trial
- Catecholaminergic Modulation of Semantic Processing in Sentence Comprehension.Cerebral cortex (New York, N.Y. : 1991) · 2020Trial
- Catecholaminergic modulation of trust decisions.Psychopharmacology · 2019Trial
- Methylphenidate modulates sustained attention and cortical activation in survivors of traumatic brain injury: a perfusion fMRI study.Psychopharmacology · 2012Trial
- Modulation of social influence by methylphenidate.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Trial
- Basolateral amygdala dopamine transmits emotional salience.Nature communications · 2026Article
- Separable dorsal raphe dopamine projections mimic the facets of a loneliness-like state.eLife · 2025Article
- Neural basis for individual differences in the attention-enhancing effects of methylphenidate.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Behavioral Animal Models and Neural-Circuit Framework of Depressive Disorder.Neuroscience bulletin · 2025Review
- Maternal Separation Exhibits a Sex Dimorphism in Memory Impairments in Adolescent Rats: Acute Methylphenidate Administration as a Treatment.Birth defects research · 2025Article
- Article
- High emotional reactivity is associated with activation of a molecularly distinct hippocampal-amygdala circuit modulated by the glucocorticoid receptor.Neurobiology of stress · 2023Article
- Toward a Unifying Account of Dopamine's Role in Cost-Benefit Decision Making.Biological psychiatry global open science · 2023Review
- Article
- History-dependent dopamine release increases cAMP levels in most basal amygdala glutamatergic neurons to control learning.Cell reports · 2022Article
- Amygdala-hippocampal innervation modulates stress-induced depressive-like behaviors through AMPA receptors.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Social Regulation of Negative Valence Systems During Development.Frontiers in systems neuroscience · 2021Review
- Aversion hot spots in the dopamine system.Current opinion in neurobiology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Although methylphenidate (Ritalin) has been used therapeutically for nearly 60 years, the mechanisms by which it acutely modifies behavioral performance are poorly understood. Here we combined intra-lateral amygdala in vivo pharmacology and ex vivo electrophysiology to show that acute administration of methylphenidate, as well as a selective dopamine transporter inhibitor, facilitated learning-induced strengthening of cortico-amygdala synapses through a postsynaptic increase in AMPA receptor-mediated currents, relative to those in saline-treated rats. Furthermore, local administration of methylphenidate in the lateral amygdala enhanced cue-reward learning through dopamine D1 receptor-dependent mechanisms and suppressed task-irrelevant behavior through D2 receptor-dependent mechanisms. These findings reveal critical and distinct roles for dopamine receptor subtypes in mediating methylphenidate-induced enhancements of neural transmission and learning performance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.