ArticleJournal of lipid research2010
Multimodal CARS microscopy determination of the impact of diet on macrophage infiltration and lipid accumulation on plaque formation in ApoE-deficient mice.
Article in Journal of lipid research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 76 citations in OpenAlex.
- Development of an image classification pipeline for atherosclerotic plaques assessment using supervised machine learning.BMC bioinformatics · 2022Article
- Optical Imaging of Beta-Amyloid Plaques in Alzheimer's Disease.Biosensors · 2021Review
- Optical coherence tomography and multiphoton microscopy offer new options for the quantification of fibrotic aortic valve disease in ApoEScientific reports · 2021Article
- Widely-tunable synchronisation-free picosecond laser source for multimodal CARS, SHG, and two-photon microscopy.Biomedical optics express · 2021Article
- Label-Free Multiphoton Microscopy for the Detection and Monitoring of Calcific Aortic Valve Disease.Frontiers in cardiovascular medicine · 2021Review
- Article
- Bile acid sequestration reverses liver injury and prevents progression of nonalcoholic steatohepatitis in Western diet-fed mice.The Journal of biological chemistry · 2020Article
- The Sodium-Glucose Cotransporter 2 Inhibitor Dapagliflozin Prevents Renal and Liver Disease in Western Diet Induced Obesity Mice.International journal of molecular sciences · 2018Article
- Label-free imaging of atherosclerotic plaques using third-harmonic generation microscopy.Biomedical optics express · 2018Article
- Early PQQ supplementation has persistent long-term protective effects on developmental programming of hepatic lipotoxicity and inflammation in obese mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Obesity but not high-fat diet impairs lymphatic function.International journal of obesity (2005) · 2016Article
- G Protein-Coupled Bile Acid Receptor TGR5 Activation Inhibits Kidney Disease in Obesity and Diabetes.Journal of the American Society of Nephrology : JASN · 2016Article
- Quantitative multimodal multiparametric imaging in Alzheimer's disease.Brain informatics · 2016Article
- Capturing relevant extracellular matrices for investigating cell migration.F1000Research · 2015Review
- Study of the development of the mouse thoracic aorta three-dimensional macromolecular structure using two-photon microscopy.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2015Article
- Selective depletion of vascular EC-SOD augments chronic hypoxic pulmonary hypertension.American journal of physiology. Lung cellular and molecular physiology · 2014Article
- A common polymorphism in extracellular superoxide dismutase affects cardiopulmonary disease risk by altering protein distribution.Circulation. Cardiovascular genetics · 2014Article
- Endoplasmic reticulum stress effector CCAAT/enhancer-binding protein homologous protein (CHOP) regulates chronic kidney disease-induced vascular calcification.Journal of the American Heart Association · 2014Article
- Dual activation of the bile acid nuclear receptor FXR and G-protein-coupled receptor TGR5 protects mice against atherosclerosis.PloS one · 2014Article
- The need for speed.Journal of biophotonics · 2012Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
We characterized several cellular and structural features of early stage Type II/III atherosclerotic plaques in an established model of atherosclerosis-the ApoE-deficient mouse-by using a multimodal, coregistered imaging system that integrates three nonlinear optical microscopy (NLOM) contrast mechanisms: coherent anti-Stokes Raman scattering (CARS), second harmonic generation (SHG), and two-photon excitation fluorescence (TPEF). Specifically, the infiltration of lipid-rich macrophages and the structural organization of collagen and elastin fibers were visualized by CARS, SHG, and TPEF, respectively, in thick tissue specimens without the use of exogenous labels or dyes. Label-free CARS imaging of macrophage accumulation was confirmed by histopathology using CD68 staining. A high-fat, high-cholesterol Western diet resulted in an approximate 2-fold increase in intimal plaque area, defined by CARS signals of lipid-rich macrophages. Additionally, analysis of collagen distribution within lipid-rich plaque regions revealed nearly a 4-fold decrease in the Western diet-fed mice, suggesting NLOM sensitivity to increased matrix metalloproteinase (MMP) activity and decreased smooth muscle cell (SMC) accumulation. These imaging results provide significant insight into the structure and composition of early stage Type II/III plaque during formation and allow for quantitative measurements of the impact of diet and other factors on critical plaque and arterial wall features.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.