ArticleApplied and environmental microbiology2010
Heterologous expression of the oxytetracycline biosynthetic pathway in Myxococcus xanthus.
Article in Applied and environmental microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- High-Titer Production of the Fungal Anhydrotetracycline, TAN-1612, in Engineered Yeasts.ACS synthetic biology · 2022Article
- Biotechnological production optimization of argyrins - a potent immunomodulatory natural product class.Microbial biotechnology · 2022Article
- Genetic platforms for heterologous expression of microbial natural products.Natural product reports · 2019Review
- Engineering Pseudochelin Production in Myxococcus xanthus.Applied and environmental microbiology · 2018Article
- Increasing on-target cleavage efficiency for CRISPR/Cas9-induced large fragment deletion in Myxococcus xanthus.Microbial cell factories · 2017Article
- Sampling Terrestrial Environments for Bacterial Polyketides.Molecules (Basel, Switzerland) · 2017Review
- Heterologous Production of the Marine Myxobacterial Antibiotic Haliangicin and Its Unnatural Analogues Generated by Engineering of the Biochemical Pathway.Scientific reports · 2016Article
- Biotechnology of polyketides: new breath of life for the novel antibiotic genetic pathways discovery through metagenomics.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2013Review
- Synthetic biology of antimicrobial discovery.ACS synthetic biology · 2013Review
- Article
- Heterologous expression and manipulation of three tetracycline biosynthetic pathways.Angewandte Chemie (International ed. in English) · 2012Article
- MultiMetEval: comparative and multi-objective analysis of genome-scale metabolic models.PloS one · 2012Article
- Methods and options for the heterologous production of complex natural products.Natural product reports · 2011Review
- Oxytetracycline biosynthesis.The Journal of biological chemistry · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
New natural products for drug discovery may be accessed by heterologous expression of bacterial biosynthetic pathways in metagenomic DNA libraries. However, a "universal" host is needed for this experiment. Herein, we show that Myxococcus xanthus is a potential "universal" host for heterologous expression of polyketide biosynthetic gene clusters.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.