ArticleApplied and environmental microbiology2010
Revelation by single-nucleotide polymorphism genotyping that mutations leading to a premature stop codon in inlA are common among Listeria monocytogenes isolates from ready-to-eat foods but not human listeriosis cases.
Article in Applied and environmental microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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63 citing papers in PubMed, 136 citations in OpenAlex.
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- Premature stop codons inBioscience of microbiota, food and health · 2026Article
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- Genomic analysis of Listeria monocytogenes diversity over a 10-year period in Uruguay.Scientific reports · 2025Article
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- Exploratory Genomic Marker Analysis of Virulence Patterns inFoods (Basel, Switzerland) · 2025Article
- Molecular Characterization of Virulence-Related Genes in Listeria monocytogenes Isolated from Retail Meats in Sapporo, Japan.Current microbiology · 2025Article
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- Virulence and Antimicrobial Resistance ofMicroorganisms · 2024Article
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- Evaluation of the Virulence Potential ofInternational journal of molecular sciences · 2023Article
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- A Comprehensive Virulence and Resistance Characteristics ofInternational journal of molecular sciences · 2023Article
- Whole-Genome Sequencing-Based Characterization ofApplied and environmental microbiology · 2022Article
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- Characterization of Listeria monocytogenes isolated from wildlife in central New York.Veterinary medicine and science · 2022Article
- Prevalence and Clonal Diversity of over 1,200 Listeria monocytogenes Isolates Collected from Public Access Waters near Produce Production Areas on the Central California Coast during 2011 to 2016.Applied and environmental microbiology · 2022Article
3 more citing papers are in PubMed but not listed here.
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4 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Listeria monocytogenes utilizes internalin A (InlA; encoded by inlA) to cross the intestinal barrier to establish a systemic infection. Multiple naturally occurring mutations leading to a premature stop codon (PMSC) in inlA have been reported worldwide, and these mutations are causally associated with attenuated virulence. Five inlA PMSC mutations recently discovered among isolates from France and the United States were included as additional markers in our previously described inlA single-nucleotide polymorphism (SNP) genotyping assay. This assay was used to screen >1,000 L. monocytogenes isolates from ready-to-eat (RTE) foods (n = 502) and human listeriosis cases (n = 507) for 18 inlA PMSC mutations. A significantly (P < 0.0001) greater proportion of RTE food isolates (45.0%) carried a PMSC mutation in inlA compared to human clinical isolates (5.1%). The proportion of L. monocytogenes with or without PMSC mutations in inlA was similar among isolates from different RTE food categories except for deli meats, which included a marginally higher proportion (P = 0.12) of isolates carrying a PMSC in inlA. We also analyzed the distribution of epidemic clone (EC) strains, which have been linked to the majority of listeriosis outbreaks worldwide and are overrepresented among sporadic cases in the United States. We observed a significant (P < 0.05) overrepresentation of EC strains in deli and seafood salads and a significant (P < 0.05) underrepresentation of EC strains in smoked seafood. These results provide important data to predict the human health risk of exposure to L. monocytogenes strains that differ in pathogenic potential through consumption of contaminated RTE foods.
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