ArticlePlant physiology2010
Mathematical modeling of the central carbohydrate metabolism in Arabidopsis reveals a substantial regulatory influence of vacuolar invertase on whole plant carbon metabolism.
Article in Plant physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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44 citing papers in PubMed, 120 citations in OpenAlex.
- Exogenous auxin mediates the NnARF9-NnSUS2 module to regulate sucrose synthesis in lotus leaves (Nelumbo nucifera).Planta · 2026Article
- Extensive sucrose cycling through the fructan pool of a C3 grass across a 200 to 800 μmol mol-1 atmospheric CO2 gradient.Plant physiology · 2026Article
- Resolving subcellular sucrose concentrations in plant tissues.Journal of experimental botany · 2026Review
- Carbon Dioxide Release During Photosynthesis: Connecting Gas Exchange Behavior With Biochemistry.Plant, cell & environment · 2026Review
- Cytosolic fructose - an underestimated player in the regulation of sucrose biosynthesis.BMC plant biology · 2025Article
- Plant cold acclimation and its impact on sensitivity of carbohydrate metabolism.NPJ systems biology and applications · 2025Article
- Multiscale Mathematical Modeling in Systems Biology: A Framework to Boost Plant Synthetic Biology.Plants (Basel, Switzerland) · 2025Review
- Functional Characterization of JcSWEET12 and JcSWEET17a from Physic Nut.International journal of molecular sciences · 2024Article
- Far-Red Light Mediated Carbohydrate Concentration Changes in Leaves of Sweet Basil, a Stachyose Translocating Plant.International journal of molecular sciences · 2023Article
- Genome-wide association analysis reveals new insights into the genetic architecture of defensive, agro-morphological and quality-related traits in cassava.Plant molecular biology · 2022Article
- Reimport of carbon from cytosolic and vacuolar sugar pools into the Calvin-Benson cycle explains photosynthesis labeling anomalies.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Plant SWEET Family of Sugar Transporters: Structure, Evolution and Biological Functions.Biomolecules · 2022Review
- Antagonistic Effect of Sucrose Availability and Auxin onFrontiers in plant science · 2022Article
- Sucrose promotes stem branching through cytokinin.Plant physiology · 2021Article
- Impaired chloroplast positioning affects photosynthetic capacity and regulation of the central carbohydrate metabolism during cold acclimation.Photosynthesis research · 2021Article
- Indications for a Central Role of Hexokinase Activity in Natural Variation of Heat Acclimation inPlants (Basel, Switzerland) · 2020Article
- Resolving subcellular plant metabolism.The Plant journal : for cell and molecular biology · 2019Article
- Dynamics of Plant Metabolism during Cold Acclimation.International journal of molecular sciences · 2019Review
- Mathematical modeling of diurnal patterns of carbon allocation to shoot and root inNPJ systems biology and applications · 2019Article
- Functional Characterization of Invertase Inhibitors PtC/VIF1 and 2 Revealed Their Involvements in the Defense Response to Fungal Pathogen inFrontiers in plant science · 2019Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A mathematical model representing metabolite interconversions in the central carbohydrate metabolism of Arabidopsis (Arabidopsis thaliana) was developed to simulate the diurnal dynamics of primary carbon metabolism in a photosynthetically active plant leaf. The model groups enzymatic steps of central carbohydrate metabolism into blocks of interconverting reactions that link easily measurable quantities like CO(2) exchange and quasi-steady-state levels of soluble sugars and starch. When metabolite levels that fluctuate over diurnal cycles are used as a basic condition for simulation, turnover rates for the interconverting reactions can be calculated that approximate measured metabolite dynamics and yield kinetic parameters of interconverting reactions. We used experimental data for Arabidopsis wild-type plants, accession Columbia, and a mutant defective in vacuolar invertase, AtbetaFruct4, as input data. Reducing invertase activity to mutant levels in the wild-type model led to a correct prediction of increased sucrose levels. However, additional changes were needed to correctly simulate levels of hexoses and sugar phosphates, indicating that invertase knockout causes subsequent changes in other enzymatic parameters. Reduction of invertase activity caused a decline in photosynthesis and export of reduced carbon to associated metabolic pathways and sink organs (e.g. roots), which is in agreement with the reported contribution of vacuolar invertase to sink strength. According to model parameters, there is a role for invertase in leaves, where futile cycling of sucrose appears to have a buffering effect on the pools of sucrose, hexoses, and sugar phosphates. Our data demonstrate that modeling complex metabolic pathways is a useful tool to study the significance of single enzyme activities in complex, nonintuitive networks.
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