ArticleAcademic radiology2010
Gold nanoparticle contrast in a phantom and juvenile swine: models for molecular imaging of human organs using x-ray computed tomography.
Article in Academic radiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 87 citations in OpenAlex.
- New Approaches in Breast Cancer Therapy Through Green Nanotechnology and Nano-Ayurvedic Medicine - Pre-Clinical and Pilot Human Clinical Investigations.International journal of nanomedicine · 2020Trial
- Green Nanotechnology and Phytochemical Mediated Production of Ketone Encapsulated Protein Nanoparticles-in vitro and in vivo Bioavailability Investigations.Nanotechnology, science and applications · 2025Article
- Anticarcinogenic Effects of Gold Nanoparticles and Metformin Against MCF-7 and A549 Cells.Biological trace element research · 2024Article
- Observation of targeted gold nanoparticles in nasopharyngeal tumour nude mice model through dual-energy computed tomography.IET nanobiotechnology · 2021Article
- Analysis of the Exposure of Organisms to the Action of Nanomaterials.Materials (Basel, Switzerland) · 2020Review
- Species-Specific in vitro and in vivo Evaluation of Toxicity of Silver Nanoparticles Stabilized with Gum Arabic Protein.International journal of nanomedicine · 2020Article
- Applications of nanoparticles in biomedical imaging.Nanoscale · 2019Review
- Development of resveratrol-conjugated gold nanoparticles: interrelationship of increased resveratrol corona on anti-tumor efficacy against breast, pancreatic and prostate cancers.International journal of nanomedicine · 2019Article
- Green synthesis of gold nanoparticles usingIET nanobiotechnology · 2017Article
- Biofabrication of nanogold from the flower extracts of Lantana camara.IET nanobiotechnology · 2016Article
- CT Image Contrast of High-Z Elements: Phantom Imaging Studies and Clinical Implications.Radiology · 2016Article
- Advanced targeted nanomedicine.Journal of biotechnology · 2015Article
- Optimization of K-edge imaging for vulnerable plaques using gold nanoparticles and energy resolved photon counting detectors: a simulation study.Physics in medicine and biology · 2014Article
- Nanotechnology for computed tomography: a real potential recently disclosed.Pharmaceutical research · 2014Review
- Gum arabic-coated radioactive gold nanoparticles cause no short-term local or systemic toxicity in the clinically relevant canine model of prostate cancer.International journal of nanomedicine · 2014Article
- In vivo characterization of tumor vasculature using iodine and gold nanoparticles and dual energy micro-CT.Physics in medicine and biology · 2013Article
- DNA damage enhancement from gold nanoparticles for clinical MV photon beams.Radiation research · 2012Article
- Personalized nanomedicine advancements for stem cell tracking.Advanced drug delivery reviews · 2012Review
- X-ray imaging of tumor growth in live mice by detecting gold-nanoparticle-loaded cells.Scientific reports · 2012Article
- The application of nanoparticles in gene therapy and magnetic resonance imaging.Microscopy research and technique · 2011Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
RATIONALE AND
objectivesThe purpose of this study was to demonstrate the application of gold nanoparticles (AuNP) as a contrast agent for a clinical x-ray computed tomography (CT) system using a phantom and juvenile swine. MATERIALS AND
methodsA tissue-mimicking phantom with spherical inclusions containing known concentrations of Au was scanned. Swine were injected with gum Arabic stabilized Au nanoparticles (GA-AuNP), up to 85 mg kg(-1) body weight. CT scans were performed before and after the injections. Changes in Hounsfield unit (HU) values between pre- and post- injection scans were evaluated and compared to postmortem determinations of Au uptake. Average uptake of GA-AuNP in the liver of the swine was 380 microg per gram of liver and 680 microg per gram of spleen.
resultsConcentrations of Au in tissues increased the CT numbers in liver by approximately 22 HU per mg Au concentration at 80 kVp and 27 HU per mg Au concentration at 140 kVp. These data were consistent with HU changes observed for similar concentrations in the phantom.
conclusionsAuNP-based contrast agents may be useful in x-ray based CT. This study provides data for determining concentrations of AuNP in comparison to other contrast materials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.