ReviewProstaglandins, leukotrienes, and essential fatty acids
N-3 vs. saturated fatty acids: effects on the arterial wall.
Review in Prostaglandins, leukotrienes, and essential fatty acids. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 61 citations in OpenAlex.
- Different gene expression profiles in normo- and dyslipidemic men after fish oil supplementation: results from a randomized controlled trial.Lipids in health and disease · 2012Trial
- Role of Anti-Inflammatory and Antioxidant Properties of Natural Products in Curing Cardiovascular Diseases.Current issues in molecular biology · 2025Review
- How the Dietary Saturated/Monounsaturated Fatty Acid Ratio Modulates Brain Function in Older Adults.Nutrients · 2025Review
- Therapeutic Potential of Select Dietary Compounds in the Management of Hypertension and its Cardiovascular Complications.Molecules (Basel, Switzerland) · 2022Review
- Intake of food rich in saturated fat in relation to subclinical atherosclerosis and potential modulating effects from single genetic variants.Scientific reports · 2021Article
- Long-Chain Acylcarnitines and Monounsaturated Fatty Acids Discriminate Heart Failure Patients According to Pulmonary Hypertension Status.Metabolites · 2021Article
- A Nutritional Supplement (DìLshAnimals : an open access journal from MDPI · 2020Article
- Circulating serum fatty acid synthase is elevated in patients with diabetes and carotid artery stenosis and is LDL-associated.Atherosclerosis · 2019Article
- Effects of a nutritional supplement in dogs affected by osteoarthritis.Veterinary medicine and science · 2019Article
- Clinical and Immunological Response in Dogs Naturally Infected byAnimals : an open access journal from MDPI · 2019Article
- Are Polyunsaturated Fatty Acids Implicated in Histaminergic Dysregulation in Bipolar Disorder?: AN HYPOTHESIS.Frontiers in physiology · 2018Review
- Influence of breastfeeding and postnatal nutrition on cardiovascular remodeling induced by fetal growth restriction.Pediatric research · 2016Article
- A flood of health functional foods: what is to be recommended?Journal of menopausal medicine · 2015Review
- Article
- Triolein and trilinolein ameliorate oxidized low-density lipoprotein-induced oxidative stress in endothelial cells.Lipids · 2014Article
- Omega-3 fatty acids: mechanisms underlying 'protective effects' in atherosclerosis.Current opinion in lipidology · 2013Review
- A fish a day, keeps the cardiologist away! - A review of the effect of omega-3 fatty acids in the cardiovascular system.Indian journal of endocrinology and metabolism · 2013Article
- Modification of high saturated fat diet with n-3 polyunsaturated fat improves glucose intolerance and vascular dysfunction.Diabetes, obesity & metabolism · 2013Article
- Transcriptome-based identification of antioxidative gene expression after fish oil supplementation in normo- and dyslipidemic men.Nutrition & metabolism · 2012Article
- The omega-3 fatty acid nutritional landscape: health benefits and sources.The Journal of nutrition · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cardiovascular disease is a leading cause of death worldwide. Atherosclerosis and unstable plaques are underlying causes for cardiovascular diseases. Cardiovascular disease is associated with consumption of diets high in saturated fats. In contrast there is increasing evidence that higher intakes of dietary n-3 fatty acids decrease risk for cardiovascular disease. Recent studies are beginning to clarify how n-3 compared with saturated fatty acids influence cardiovascular disease risk via pathways in the arterial wall. In this paper we will review studies that report on mechanisms whereby dietary fatty acids affect atherosclerosis through modulation of arterial wall lipid deposition, inflammation, cell proliferation, and plaque vulnerability.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.