ArticleAquatic toxicology (Amsterdam, Netherlands)2010
Arsenic inhibits SGK1 activation of CFTR Cl- channels in the gill of killifish, Fundulus heteroclitus.
Article in Aquatic toxicology (Amsterdam, Netherlands), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- A Non-Channel Function of CFTR: Attenuating Mitochondrial Oxidative Stress and Cardiomyocyte Senescence via Stabilization by USP45.Aging cell · 2026Article
- Prolactin, cortisol, and extracellular osmolality regulateFrontiers in endocrinology · 2026Article
- Article
- Trace metals in the teleost fish gill: biological roles, uptake regulation, and detoxification mechanisms.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024Review
- Profiling microRNA expression in Atlantic killifish (Fundulus heteroclitus) gill and responses to arsenic and hyperosmotic stress.Aquatic toxicology (Amsterdam, Netherlands) · 2019Article
- Arsenic Reduces Gene Expression Response to Changing Salinity in Killifish.Environmental science & technology · 2018Article
- Serum and Glucocorticoid Regulated Kinase 1 in Sodium Homeostasis.International journal of molecular sciences · 2016Review
- Advancing toxicology research using in vivo high throughput toxicology with small fish models.ALTEX · 2016Article
- A novel variant of aquaporin 3 is expressed in killifish (Fundulus heteroclitus) intestine.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2015Article
- Testing multiple hypotheses through IMP weighted FDR based on a genetic functional network with application to a new zebrafish transcriptome study.BioData mining · 2015Article
- Natural selection canalizes expression variation of environmentally induced plasticity-enabling genes.Molecular biology and evolution · 2014Article
- cGMP inhibition of type 3 phosphodiesterase is the major mechanism by which C-type natriuretic peptide activates CFTR in the shark rectal gland.American journal of physiology. Cell physiology · 2014Article
- Article
- Early life arsenic exposure and acute and long-term responses to influenza A infection in mice.Environmental health perspectives · 2013Article
- Arsenic immunotoxicity: a review.Environmental health : a global access science source · 2013Review
- Arsenic promotes ubiquitinylation and lysosomal degradation of cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels in human airway epithelial cells.The Journal of biological chemistry · 2012Article
- A novel aquaporin 3 in killifish (Fundulus heteroclitus) is not an arsenic channel.Toxicological sciences : an official journal of the Society of Toxicology · 2012Article
- Expression of aquaporin 3 in gills of the Atlantic killifish (Fundulus heteroclitus): Effects of seawater acclimation.Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · 2012Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Seawater acclimation in killifish, Fundulus heteroclitus, is mediated in part by a rapid (1h) translocation of CFTR Cl(-) channels from an intracellular pool to the plasma membrane in gill and increased CFTR-mediated Cl(-) secretion. This effect is mediated by serum and glucocorticoid-inducible kinase 1 (SGK1), which is stimulated by plasma hypertonicity rather than cortisol. Since arsenic exposure prevents acclimation to seawater by decreasing CFTR protein levels we tested the hypothesis that arsenic (as sodium arsenite) blocks acclimation to seawater by down regulating SGK1 expression. Freshwater adapted killifish were exposed to arsenic (48h) and transferred to seawater containing arsenic, and SGK and CFTR expression were measured. Arsenic reduced the seawater induced increase in SGK1 mRNA and protein abundance, and reduced both the total amount of CFTR and the amount of CFTR in the plasma membrane. The decrease in membrane CFTR reduced Cl(-) secretion. Arsenic also increased the amount of ubiquitinated CFTR and its degradation by the lysosome. Thus, we propose a model whereby arsenic reduces the ability of killifish to acclimate to seawater by blocking the seawater induced increase in SGK1, which results in increased ubiquitination and degradation of CFTR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.