Evidence map›Paper›PMID 20206987›Full record

ReviewLancet (London, England)2010

Community-associated meticillin-resistant Staphylococcus aureus.

Frank R DeLeo, Michael Otto, Barry N Kreiswirth, Henry F Chambers

Open access · greenAbstract readReview
In one paragraph

Review in Lancet (London, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 632 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
632citing papers in PubMed, 1 pooled it
73.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

632 citing papers in PubMed, 1 synthesis or guideline pooled it, 1,482 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Genomic diversity and topical antimicrobial resistance inAntimicrobial agents and chemotherapy · 2026
    Article
  5. The global epidemiology of MRSA.JAC-antimicrobial resistance · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Antimicrobial resistance and zinc resistance geneFrontiers in microbiology · 2026
    Article
  12. Emergence of a methicillin-susceptibleFrontiers in cellular and infection microbiology · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

572 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Frank R DeLeoLaboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. fdeleo@niaid.nih.gov
Michael Otto
Barry N Kreiswirth
Henry F Chambers
National Institutes of Health · USInternational Center for Public Health · USUniversity of California, San Francisco · US

Funding

Staphylococcal pathogenesisZIAAI000904 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI OTTO, MICHAEL · 2009 to 2025
$22.6M
Mechanisms of Staphylococcus aureus virulenceZIAAI001079 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI DELEO, FRANK · 2009 to 2025
$11.8M
Genetic Basis of Virulence of Community MRSA Clone USA300R01AI070289 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HENRY CHAMBERS, HENRY F · 2008 to 2010
$1.2M
Intramural NIH HHS ZIA AI001079NIAID NIH HHS AI070289NIAID NIH HHS R01 AI070289
6 · The paper itself

Abstract

Meticillin-resistant Staphylococcus aureus (MRSA) is endemic in hospitals worldwide, and causes substantial morbidity and mortality. Health-care-associated MRSA infections arise in individuals with predisposing risk factors, such as surgery or presence of an indwelling medical device. By contrast, many community-associated MRSA (CA-MRSA) infections arise in otherwise healthy individuals who do not have such risk factors. Additionally, CA-MRSA infections are epidemic in some countries. These features suggest that CA-MRSA strains are more virulent and transmissible than are traditional hospital-associated MRSA strains. The restricted treatment options for CA-MRSA infections compound the effect of enhanced virulence and transmission. Although progress has been made towards understanding emergence of CA-MRSA, virulence, and treatment of infections, our knowledge remains incomplete. Here we review the most up-to-date knowledge and provide a perspective for the future prophylaxis or new treatments for CA-MRSA infections.

Indexed as

Anti-Bacterial AgentsBacterial ToxinsCommunity-Acquired InfectionsDrainageExotoxinsHumansLeukocidinsMethicillin-Resistant Staphylococcus aureusNasal CavityStaphylococcal InfectionsAnti-Bacterial AgentsBacterial ToxinsExotoxinsLeukocidinsPanton-Valentine leukocidin

Identifiers

PMID20206987
PMCPMC3511788
OpenAlexW2116607488

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.