ArticleVirus research2010
Complete genome sequences of avian paramyxovirus serotype 6 prototype strain Hong Kong and a recent novel strain from Italy: evidence for the existence of subgroups within the serotype.
Article in Virus research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 42 citations in OpenAlex.
- Genetic diversity and molecular characterization of avian paramyxoviruses from wild birds in South Korea between 2020 and 2024.Frontiers in microbiology · 2026Article
- Long-term surveillance of avian avulavirus in wild birds in China from 2003 to 2020.Virologica Sinica · 2025Article
- Discovery of Avian Paramyxoviruses APMV-1 and APMV-6 in Shorebirds and Waterfowl in Southern Ukraine.Viruses · 2023Article
- Avian Paramyxovirus 4 Antitumor Activity Leads to Complete Remissions and Long-term Protective Memory in Preclinical Melanoma and Colon Carcinoma Models.Cancer research communications · 2022Article
- Putative Novel Avian Paramyxovirus (AMPV) and Reidentification of APMV-2 and APMV-6 to the Species Level Based on Wild Bird Surveillance (United States, 2016-2018).Applied and environmental microbiology · 2022Article
- Genetic and Antigenic Characterization of Avian Avulavirus Type 6 (AAvV-6) Circulating in Canadian Wild Birds (2005-2017).Viruses · 2021Article
- Molecular evolution and genetic variations of V and W proteins derived by RNA editing in Avian Paramyxoviruses.Scientific reports · 2020Article
- Biological and phylogenetic characterization of a novel hemagglutination-negative avian avulavirus 6 isolated from wild waterfowl in China.Transboundary and emerging diseases · 2018Article
- Metagenomics detection and characterisation of viruses in faecal samples from Australian wild birds.Scientific reports · 2018Article
- Avian viral surveillance in Victoria, Australia, and detection of two novel avian herpesviruses.PloS one · 2018Article
- Characterization of avian paramyxovirus type 6 isolated from a Eurasian teal in the intersection of migratory flyways in Russia.Archives of virology · 2016Article
- Completion of full length genome sequence of novel avian paramyxovirus strain APMV/Shimane67 isolated from migratory wild geese in Japan.The Journal of veterinary medical science · 2016Article
- Circulation of avian paramyxoviruses in wild birds of Kazakhstan in 2002-2013.Virology journal · 2016Article
- Characterization of novel avian paramyxovirus strain APMV/Shimane67 isolated from migratory wild geese in Japan.The Journal of veterinary medical science · 2015Article
- Complete Genome Sequence of Avian Paramyxovirus Strain APMV-6/red-crested pochard/Balkhash/5842/2013 from Kazakhstan.Genome announcements · 2015Article
- Effects of naturally occurring six- and twelve-nucleotide inserts on Newcastle disease virus replication and pathogenesis.PloS one · 2014Article
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- Evaluation of the genetic diversity of avian paramyxovirus type 4.Virus research · 2013Article
- Complete nucleotide sequence of avian paramyxovirus type 6 strain JL isolated from mallard ducks in China.Journal of virology · 2012Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Complete genome sequences were determined for two strains of avian paramyxovirus serotype 6 (APMV-6): the prototype Hong Kong (HK) strain and a more recent isolate from Italy (IT4524-2). The genome length of strain HK is 16236 nucleotide (nt), which is the same as for the other two APMV-6 strains (FE and TW) that have been reported to date, whereas that of strain IT4524-2 is 16230 nt. The length difference in strain IT4524-2 is due to a 6-nt deletion in the downstream untranslated region of the F gene. All of these viruses follow the "rule of six". Each genome consists of seven genes in the order of 3'N-P-M-F-SH-HN-L5', which differs from other APMV serotypes in containing an additional gene encoding the small hydrophobic (SH) protein. Sequence comparisons revealed that strain IT4524-2 shares an unexpectedly low level of genome nt sequence identity (70%) and aggregate predicted amino acid (aa) sequence identity (79%) with other three strains, which in contrast are more closely related to each other with nt sequence 94-98% nt identity and 90-100% aggregate aa identity. Sequence analysis of the F-SH-HN genome region of two other recent Italian isolates showed that they fall in the HK/FE/TW group. The predicted signal peptide of IT4524-2 F protein lacks the N-terminal first 10 aa that are present in the other five strains. Also, the F protein cleavage site of strain IT4524-2, REPR downward arrow L, has two dibasic aa (arginine, R) compared to the monobasic F protein cleavage site of PEPR downward arrow L in the other strains. Reciprocal cross-hemagglutination inhibition (HI) assays using post-infection chicken sera indicated that strain IT4524-2 is antigenically related to the other APMV-6 strains, but with 4- to 8-fold lower HI tiers for the test sera between strain IT4524-2 and the other APMV-6 strains. Taken together, our results indicated that the APMV-6 strains represents a single serotype with two subgroups that differ substantially based on nt and aa sequences and can be distinguished by HI assay.
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