ArticleBMC cancer2010
Maternal consumption of canola oil suppressed mammary gland tumorigenesis in C3(1) TAg mice offspring.
Article in BMC cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 45 citations in OpenAlex.
- Dietary walnut altered gene expressions related to tumor growth, survival, and metastasis in breast cancer patients: a pilot clinical trial.Nutrition research (New York, N.Y.) · 2019Trial
- Nutrients Lowering Obesity-Linked Chemokines Blamable for Metastasis.International journal of molecular sciences · 2025Review
- Maternal fish oil consumption has a negative impact on mammary gland tumorigenesis in C3(1) Tag mice offspring.European journal of nutrition · 2021Article
- Epigenetic Reprogramming Mediated by Maternal Diet Rich in Omega-3 Fatty Acids Protects From Breast Cancer Development in F1 Offspring.Frontiers in cell and developmental biology · 2021Article
- The Mediterranean Diet and Breast Cancer: A Personalised Approach.Healthcare (Basel, Switzerland) · 2019Review
- The effect of "NutramilTM Complex," food for special medical purpose, on breast and prostate carcinoma cells.PloS one · 2018Article
- The effects of omega-3 polyunsaturated Fatty Acid consumption on mammary carcinogenesis.Lipids · 2015Review
- The role of n-3 polyunsaturated fatty acids in the prevention and treatment of breast cancer.Nutrients · 2014Review
- Diet components can suppress inflammation and reduce cancer risk.Nutrition research and practice · 2014Review
- Exposure to lard-based high-fat diet during fetal and lactation periods modifies breast cancer susceptibility in adulthood in rats.The Journal of nutritional biochemistry · 2014Article
- Walnuts have potential for cancer prevention and treatment in mice.The Journal of nutrition · 2014Review
- Evidence of health benefits of canola oil.Nutrition reviews · 2013Review
- Article
- Effects of omega-3 fatty acids on progestin stimulation of invasive properties in breast cancer.Hormones & cancer · 2012Review
- Lactation and neonatal nutrition: defining and refining the critical questions.Journal of mammary gland biology and neoplasia · 2012Article
- Consumption of high ω-3 fatty acid diet suppressed prostate tumorigenesis in C3(1) Tag mice.Carcinogenesis · 2012Article
- Dietary walnut suppressed mammary gland tumorigenesis in the C(3)1 TAg mouse.Nutrition and cancer · 2011Article
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3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundMaternal consumption of a diet high in omega 6 polyunsaturated fats (n-6 PUFA) has been shown to increase risk whereas a diet high in omega 3 polyunsaturated fats (n-3 PUFA) from fish oil has been shown to decrease risk for mammary gland cancer in female offspring of rats. The aim of this study was to determine whether increasing n-3 PUFA and reducing n-6 PUFA by using canola oil instead of corn oil in the maternal diet might reduce the risk for breast cancer in female offspring.
methodsFemale SV 129 mice were divided into two groups and placed on diets containing either 10% w/w corn oil (which is 50% n-6 PUFA, control diet) or 10% w/w canola oil (which is 20% n-6 PUFA, 10% n-3 PUFA, test diet). After two weeks on the diets the females were bred with homozygous C3(1) TAg transgenic mice. Mother mice consumed the assigned diet throughout gestation and nursing of the offspring. After weaning, all female offspring were maintained on the control diet.
resultsCompared to offspring of mothers fed the corn oil diet (CO/CO group), offspring of mothers fed the canola oil diet (CA/CO group) had significantly fewer mammary glands with tumors throughout the experiment. At 130 days of age, the CA/CO group had significantly fewer tumors per mouse (multiplicity); the tumor incidence (fraction of mice with any tumor) and the total tumor weight (per mouse that developed tumor) was less than one half that of the CO/CO group. At 170 days of age, the total tumor weight per mouse was significantly less in the CA/CO group and if a tumor developed the rate of tumor growth rate was half that of CO/CO group. These results indicate that maternal consumption of canola oil was associated with delayed appearance of mammary gland tumors and slowed growth of the tumors that developed.
conclusionsSubstituting canola oil for corn oil is an easy dietary change for people to make; such a change to the maternal diet may decrease risk for breast cancer in the daughter.
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