ArticleJournal of the International Society of Sports Nutrition2010
Creatine supplementation spares muscle glycogen during high intensity intermittent exercise in rats.
Article in Journal of the International Society of Sports Nutrition, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 32 citations in OpenAlex.
- Creatine supplementation prevents acute strength loss induced by concurrent exercise.European journal of applied physiology · 2014Trial
- Revision of Energy Metabolism Adaptations in High-Level Athletes: From Physical Performance Enhancement to Potential Therapeutic Targets in Mental Disorders.Current issues in molecular biology · 2026Review
- Variables Influencing the Effectiveness of Creatine Supplementation as a Therapeutic Intervention for Sarcopenia.Frontiers in nutrition · 2019Review
- Dietary Creatine Supplementation in Gilthead Seabream (Frontiers in physiology · 2018Article
- The effect of combined supplementation of carbohydrates and creatine on anaerobic performance.Biology of sport · 2017Article
- Continuous metabolic monitoring based on multi-analyte biomarkers to predict exhaustion.Scientific reports · 2015Article
- Contribution of creatine to protein homeostasis in athletes after endurance and sprint running.European journal of nutrition · 2014Article
- Creatine monohydrate supplementation on lower-limb muscle power in Brazilian elite soccer players.Journal of the International Society of Sports Nutrition · 2014Article
- The effects of a high dosage of creatine and caffeine supplementation on the lean body mass composition of rats submitted to vertical jumping training.Journal of the International Society of Sports Nutrition · 2011Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe effects of creatine (CR) supplementation on glycogen content are still debatable. Thus, due to the current lack of clarity, we investigated the effects of CR supplementation on muscle glycogen content after high intensity intermittent exercise in rats.
methodsFirst, the animals were submitted to a high intensity intermittent maximal swimming exercise protocol to ensure that CR-supplementation was able to delay fatigue (experiment 1). Then, the CR-mediated glycogen sparing effect was examined using a high intensity intermittent sub-maximal exercise test (fixed number of bouts; six bouts of 30-second duration interspersed by two-minute rest interval) (experiment 2). For both experiments, male Wistar rats were given either CR supplementation or placebo (Pl) for 5 days.
resultsAs expected, CR-supplemented animals were able to exercise for a significant higher number of bouts than Pl. Experiment 2 revealed a higher gastrocnemius glycogen content for the CR vs. the Pl group (33.59%). Additionally, CR animals presented lower blood lactate concentrations throughout the intermittent exercise bouts compared to Pl. No difference was found between groups in soleus glycogen content.
conclusionThe major finding of this study is that CR supplementation was able to spare muscle glycogen during a high intensity intermittent exercise in rats.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.