ArticleJournal of the International AIDS Society2010
Highly active antiretroviral treatment for the prevention of HIV transmission.
Article in Journal of the International AIDS Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 118 citations in OpenAlex.
- Effect of Universal Testing and Treatment on HIV Incidence - HPTN 071 (PopART).The New England journal of medicine · 2019Trial
- HIV-related stigma and universal testing and treatment for HIV prevention and care: design of an implementation science evaluation nested in the HPTN 071 (PopART) cluster-randomized trial in Zambia and South Africa.Health policy and planning · 2016Trial
- Recent advances in carbon quantum dots for virus detection, as well as inhibition and treatment of viral infection.Nano convergence · 2022Review
- Video-Based Intervention for Improving Maternal Retention and Adherence to HIV Treatment: Patient Perspectives and Experiences.International journal of environmental research and public health · 2021Article
- Navigating Multiple Sources of Healing in the Context of HIV/AIDS and Wide Availability of Antiretroviral Treatment: A Qualitative Study of Community Participants' Perceptions and Experiences in Rural South Africa.Frontiers in public health · 2018Article
- Traditional health practitioners' management of HIV/AIDS in rural South Africa in the era of widespread antiretroviral therapy.Global health action · 2017Article
- Strengthening HIV surveillance in the antiretroviral therapy era: rationale and design of a longitudinal study to monitor HIV prevalence and incidence in the uMgungundlovu District, KwaZulu-Natal, South Africa.BMC public health · 2015Article
- Mechanism of multivalent nanoparticle encounter with HIV-1 for potency enhancement of peptide triazole virus inactivation.The Journal of biological chemistry · 2015Article
- 'I am doing fine only because I have not told anyone': the necessity of concealment in the lives of people living with HIV in India.Culture, health & sexuality · 2015Article
- Traditional health practitioners' perceptions, herbal treatment and management of HIV and related opportunistic infections.Journal of ethnobiology and ethnomedicine · 2014Article
- CD4 counts and viral loads of newly diagnosed HIV-infected individuals: implications for treatment as prevention.PloS one · 2014Article
- Potential impact of the US President's Emergency Plan for AIDS relief on the tuberculosis/HIV coepidemic in selected Sub-Saharan African countries.The Journal of infectious diseases · 2013Article
- Tracking the progress of HIV: the impact of point-of-care tests on antiretroviral therapy.Clinical epidemiology · 2013Review
- A qualitative study of barriers to enrollment into free HIV care: perspectives of never-in-care HIV-positive patients and providers in Rakai, Uganda.BioMed research international · 2013Article
- HIV among immigrants living in high-income countries: a realist review of evidence to guide targeted approaches to behavioural HIV prevention.Systematic reviews · 2012Review
- HIV status and participation in HIV surveillance in the era of antiretroviral treatment: a study of linked population-based and clinical data in rural South Africa.Tropical medicine & international health : TM & IH · 2012Article
- Behavioral and biomedical combination strategies for HIV prevention.Cold Spring Harbor perspectives in medicine · 2012Review
- Pretreatment HIV-1 drug resistance is strongly associated with virologic failure in HIV-infected patients receiving partly active antiretroviral regimens.Future microbiology · 2012Article
- The Promise of Antiretrovirals for HIV Prevention.Current infectious disease reports · 2012Article
- Medication-related barriers to entering HIV care.AIDS patient care and STDs · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In 2007 an estimated 33 million people were living with HIV; 67% resided in sub-Saharan Africa, with 35% in eight countries alone. In 2007, there were about 1.4 million HIV-positive tuberculosis cases. Globally, approximately 4 million people had been given highly active antiretroviral therapy (HAART) by the end of 2008, but in 2007, an estimated 6.7 million were still in need of HAART and 2.7 million more became infected with HIV.Although there has been unprecedented investment in confronting HIV/AIDS - the Joint United Nations Programme on HIV/AIDS estimates $13.8 billion was spent in 2008 - a key challenge is how to address the HIV/AIDS epidemic given limited and potentially shrinking resources. Economic disparities may further exacerbate human rights issues and widen the increasingly divergent approaches to HIV prevention, care and treatment.HIV transmission only occurs from people with HIV, and viral load is the single greatest risk factor for all modes of transmission. HAART can lower viral load to nearly undetectable levels. Prevention of mother to child transmission offers proof of the concept of HAART interrupting transmission, and observational studies and previous modelling work support using HAART for prevention. Although knowing one's HIV status is key for prevention efforts, it is not known with certainty when to start HAART.Building on previous modelling work, we used an HIV/AIDS epidemic of South African intensity to explore the impact of testing all adults annually and starting persons on HAART immediately after they are diagnosed as HIV positive. This theoretical strategy would reduce annual HIV incidence and mortality to less than one case per 1000 people within 10 years and it would reduce the prevalence of HIV to less than 1% within 50 years. To explore HAART as a prevention strategy, we recommend further discussions to explore human rights and ethical considerations, clarify research priorities and review feasibility and acceptability issues.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.