ArticleBMC genomics2010
Comprehensive analysis of MHC class I genes from the U-, S-, and Z-lineages in Atlantic salmon.
Article in BMC genomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 62 citations in OpenAlex.
- Farmed Escapees Threaten MHC Diversity in Wild Atlantic Salmon.Evolutionary applications · 2026Article
- Reverse vaccinology and immunoinformatics-driven design of a multiepitope vaccine candidate againstFrontiers in bioinformatics · 2026Article
- Review
- Parallel Selection in Domesticated Atlantic Salmon from Divergent Founders Including on Whole-Genome Duplication-derived Homeologous Regions.Genome biology and evolution · 2025Article
- ISGylation and E3 ubiquitin ligases: an Atlantic salmon genetic perspective.Frontiers in immunology · 2025Article
- Molecular Characterization of MHC Class I Alpha 1 and 2 Domains in Asian Seabass (International journal of molecular sciences · 2022Article
- MHC class I evolution; from Northern pike to salmonids.BMC ecology and evolution · 2021Article
- Major Histocompatibility Complex in Osteichthyes.Journal of veterinary research · 2020Article
- TheAnimals : an open access journal from MDPI · 2019Article
- Distribution of ancient α1 and α2 domain lineages between two classical MHC class I genes and their alleles in grass carp.Immunogenetics · 2019Article
- Microbial Danger Signals Control Transcriptional Induction of Distinct MHC Class I L Lineage Genes in Atlantic Salmon.Frontiers in immunology · 2019Article
- Whole genome duplications have provided teleosts with many roads to peptide loaded MHC class I molecules.BMC evolutionary biology · 2018Article
- Evolution of innate-like T cells and their selection by MHC class I-like molecules.Immunogenetics · 2016Review
- MHC and Evolution in Teleosts.Biology · 2016Review
- A nonclassical MHC class I U lineage locus in zebrafish with a null haplotypic variant.Immunogenetics · 2015Article
- A comprehensive analysis of teleost MHC class I sequences.BMC evolutionary biology · 2015Article
- The IPD and IMGT/HLA database: allele variant databases.Nucleic acids research · 2015Article
- Evolution of nonclassical MHC-dependent invariant T cells.Cellular and molecular life sciences : CMLS · 2014Review
- A prominent role for invariant T cells in the amphibian Xenopus laevis tadpoles.Immunogenetics · 2014Review
- The MHC class I genes of zebrafish.Developmental and comparative immunology · 2014Review
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe have previously sequenced more than 500 kb of the duplicated MHC class I regions in Atlantic salmon. In the IA region we identified the loci for the MHC class I gene Sasa-UBA in addition to a soluble MHC class I molecule, Sasa-ULA. A pseudolocus for Sasa-UCA was identified in the nonclassical IB region. Both regions contained genes for antigen presentation, as wells as orthologues to other genes residing in the human MHC region.
resultsThe genomic localisation of two MHC class I lineages (Z and S) has been resolved. 7 BACs were sequenced using a combination of standard Sanger and 454 sequencing. The new sequence data extended the IA region with 150 kb identifying the location of one Z-lineage locus, ZAA. The IB region was extended with 350 kb including three new Z-lineage loci, ZBA, ZCA and ZDA in addition to a UGA locus. An allelic version of the IB region contained a functional UDA locus in addition to the UCA pseudolocus. Additionally a BAC harbouring two MHC class I genes (UHA) was placed on linkage group 14, while a BAC containing the S-lineage locus SAA (previously known as UAA) was placed on LG10. Gene expression studies showed limited expression range for all class I genes with exception of UBA being dominantly expressed in gut, spleen and gills, and ZAA with high expression in blood.
conclusionHere we describe the genomic organization of MHC class I loci from the U-, Z-, and S-lineages in Atlantic salmon. Nine of the described class I genes are located in the extension of the duplicated IA and IB regions, while three class I genes are found on two separate linkage groups. The gene organization of the two regions indicates that the IB region is evolving at a different pace than the IA region. Expression profiling, polymorphic content, peptide binding properties and phylogenetic relationship show that Atlantic salmon has only one MHC class Ia gene (UBA), in addition to a multitude of nonclassical MHC class I genes from the U-, S- and Z-lineages.
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