ReviewCurrent molecular medicine2010
Perspectives on tissue interactions in development and disease.
Review in Current molecular medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Canonical Wnt signaling regulates soft palate development by mediating ciliary homeostasis.Development (Cambridge, England) · 2023Article
- Architects of Pituitary Tumour Growth.Frontiers in endocrinology · 2022Review
- Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids.Cell stem cell · 2021Review
- Pancreatic Adenocarcinoma Invasiveness and the Tumor Microenvironment: From Biology to Clinical Trials.Biomedicines · 2020Review
- Can Environmental Manipulation Help Suppress Cancer? Non-Linear Competition Among Tumor Cells in Periodically Changing Conditions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- Self-Organized Liver Microtissue on a Bio-Functional Surface: The Role of Human Adipose-Derived Stromal Cells in Hepatic Function.International journal of molecular sciences · 2020Article
- Stromal reactivity differentially drives tumour cell evolution and prostate cancer progression.Nature ecology & evolution · 2020Article
- Homeostasis Back and Forth: An Ecoevolutionary Perspective of Cancer.Cold Spring Harbor perspectives in medicine · 2017Review
- Heterocellular cadherin connections: coordinating adhesive cues in homeostasis and cancer.F1000Research · 2017Review
- An investigation of the influence of extracellular matrix anisotropy and cell-matrix interactions on tissue architecture.Journal of mathematical biology · 2016Article
- The many ways to make a luminal cell and a prostate cancer cell.Endocrine-related cancer · 2015Review
- Establishment of a syngeneic orthotopic model of prostate cancer in immunocompetent rats.Journal of toxicologic pathology · 2015Article
- The pivotal role of integrin β1 in metastasis of head and neck squamous cell carcinoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2012Article
- PPARγ isoforms differentially regulate metabolic networks to mediate mouse prostatic epithelial differentiation.Cell death & disease · 2012Article
- Exploiting evolution to treat drug resistance: combination therapy and the double bind.Molecular pharmaceutics · 2012Article
- Investigating prostate cancer tumour-stroma interactions: clinical and biological insights from an evolutionary game.British journal of cancer · 2012Article
- Altered TGF-β signaling in a subpopulation of human stromal cells promotes prostatic carcinogenesis.Cancer research · 2011Article
- Modeling stromal-epithelial interactions in disease progression.Discovery medicine · 2010Article
- Isolation and analysis of discreet human prostate cellular populations.Differentiation; research in biological diversityReview
- Hybrid models of tumor growth.Wiley interdisciplinary reviews. Systems biology and medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
From the morphogenetic movements of the three germ layers during development to the reactive stromal microenvironment in cancer, tissue interactions are vital to maintaining healthy organ morphologic architecture and function. The stromal compartment is thought to be complicit in tumor progression and, as such, represents an opportune target for disease therapies. However, recent developments in our understanding of the diversity of the stromal compartment and the lack of appropriate models to study its relevance in human disease have limited our further understanding of the role of tissue interactions in tumor progression. The failure any model to fully recapitulate the complexities of systemic biology continue to create a higher imperative for incorporating various perspectives into a broader understanding for the ultimate goal of designing interventional therapies. Understanding this potential, this review examines the biological models used to study stromal-epithelial interactions and includes an attempt to incorporate behavioral terminology to define and mathematically model ecological relationships in stromal-epithelial interactions. In addition, the current attempt to incorporate these diverse ecological perspectives into in silico mathematical models through cross-disciplinary coordination is reviewed, which will provide a fresh perspective on defining cell group behavior and tissue ecology in disease and hopefully lead to the generation of new hypotheses to be empirically validated.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.