Evidence map›Paper›PMID 20205648›Full record

ArticleCNS & neurological disorders drug targets2010

Inflammation, immunity, and Alzheimer's disease.

Terrence Town

Open access · bronzeAbstract readEditorial
In one paragraph

Article in CNS & neurological disorders drug targets, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Role of the gut microbiome in mediating sex-specific differences in the pathophysiology of Alzheimer's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
    Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Telomere shortening and Alzheimer's disease.Neuromolecular medicine · 2013
    Review
  11. Article
  12. Targeting S100B in Cerebral Ischemia and in Alzheimer's Disease.Cardiovascular psychiatry and neurology · 2010
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Terrence Town
Cedars-Sinai Medical Center · US

Funding

Blocking TGF-Beta immune signaling as a therapeutic target for Alzheimer's diseasR00AG029726 · NIA · CEDARS-SINAI MEDICAL CENTER · PI TOWN, TERRENCE C · 2008 to 2010
$790k
NIA NIH HHS R00 AG029726
6 · The paper itself

Abstract

Few topics in the field of Alzheimer's disease (AD) research have brought about the level of excitement and interest as the role of inflammation and immunity in the pathobiology and treatment of the disease. In this special issue of the journal, experts in the field give their views on how inflammatory processes and the immune system intersect- at both etiological and treatment levels- with disease biology. Collectively, nearly three decades of work are covered in this special issue, beginning with the first epidemiologic studies that showed an inverse risk relationship between AD and use of non-steroidal anti-inflammatory drugs, and ending with "immunotherapy" approaches and recent studies examining the roles of innate immune cells including microglia and peripheral mononuclear phagocytes in AD. Despite considerable work in this area, many important questions remain concerning the nature and timing of immune/inflammatory responses in the context of AD, and at what point and how to therapeutically intervene.

Indexed as

Alzheimer DiseaseAlzheimer VaccinesAnti-Inflammatory Agents, Non-SteroidalAutoimmunityEncephalitisImmune SystemImmunity, InnateMicrogliaAlzheimer VaccinesAnti-Inflammatory Agents, Non-Steroidal

Identifiers

PMID20205648
PMCPMC2855399
OpenAlexW1540733413

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.