ArticleJournal of Zhejiang University. Science. B2010
Science letters: Proteomic analysis of differentially expressed proteins in mice with concanavalin A-induced hepatitis.
Article in Journal of Zhejiang University. Science. B, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 9 citations in OpenAlex.
- In-depth identification of pathways related to cisplatin-induced hepatotoxicity through an integrative method based on an informatics-assisted label-free protein quantitation and microarray gene expression approach.Molecular & cellular proteomics : MCP · 2012Article
- A microarray analysis of early activated pathways in concanavalin A-induced hepatitis.Journal of Zhejiang University. Science. B · 2010Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
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Abstract
objectiveTo find new protein biomarkers for the detection and evaluation of liver injury and to analyze the relationship between such proteins and disease progression in concanavalin A (Con A)-induced hepatitis.
methodsTwenty-five mice were randomly divided into five groups: an untreated group, a control group injected with phosphate buffered saline (PBS), and groups with Con A-induced hepatitis evaluated at 1, 3 and 6 h. Two-dimensional gel electrophoresis (2-DE) and mass spectrometry (MS) were used to identify differences in protein expression among groups. Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to verify the results.
resultsIn mice with Con A-induced hepatitis, expression levels of four proteins were increased: RIKEN, fructose bisphosphatase 1 (fbp1), ketohexokinase (khk), and Chain A of class pi glutathione S-transferase. Changes in fbp1 and khk were confirmed by qRT-PCR.
conclusionLevels of two proteins, fbp1 and khk, are clearly up-regulated in mice with Con A-induced hepatitis.
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