ArticleStatistics in medicine2010
A metastasis or a second independent cancer? Evaluating the clonal origin of tumors using array copy number data.
Article in Statistics in medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Epigenomic alterations in breast carcinoma from primary tumor to locoregional recurrences.PloS one · 2014Trial
- Dual primary malignancies in Kashmir: A five-year analysis of temporal patterns, gender-specific presentations and treatment outcomes in a high gastrointestinal cancer risk population.Journal of family medicine and primary care · 2026Review
- Laryngeal Adenoid Cystic Carcinoma-Two Case Reports and Literature Review.Case reports in pathology · 2026Article
- Article
- Unraveling Tumor-to-Tumor Metastasis: Insights into Pathogenesis, Diagnostic Challenges, and Treatment Modalities.Biologics : targets & therapy · 2025Review
- Clonal Patterns Between Pouch Neoplasia and Prior Colorectal Neoplasia in Inflammatory Bowel Disease Patients: An Exploratory Cohort Study.Inflammatory bowel diseases · 2023Article
- Pattern and risk factors of isolated local relapse among women with hormone receptor-positive and HER2-negative breast cancer and lymph node involvement: 10-year follow-up analysis of the PACS 01 and PACS 04 trials.Breast cancer research and treatment · 2023Article
- Long-Term Care and Follow-Up in Laryngeal Cancer Patients: A Multicenter Retrospective Analysis.Journal of personalized medicine · 2023Article
- Case Report: A case of synchronous right upper lobe adenocarcinoma and left lower lobe squamous cell carcinoma treated with immune checkpoint inhibitor plus chemotherapy.Frontiers in oncology · 2023Article
- Evaluating statistical approaches to define clonal origin of tumours using bulk DNA sequencing: context is everything.Genome biology · 2022Review
- Mutational landscape of multiple primary lung cancers and its correlation with non-intrinsic risk factors.Scientific reports · 2021Article
- Testing tumors from different anatomic sites for clonal relatedness using somatic mutation data.Biometrics · 2021Article
- Two types of primary mucinous ovarian tumors can be distinguished based on their origin.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2020Article
- Colorectal metastasis to the gallbladder mimicking a primary gallbladder malignancy: histopathological and molecular characteristics.Histopathology · 2019Article
- Redefining synchronous colorectal cancers based on tumor clonality.International journal of cancer · 2019Article
- Article
- Germline Predisposition and Copy Number Alteration in Pre-stage Lung Adenocarcinomas Presenting as Ground-Glass Nodules.Frontiers in oncology · 2019Article
- Estimating the probability of clonal relatedness of pairs of tumors in cancer patients.Biometrics · 2018Article
- Contralateral breast cancers: Independent cancers or metastases?International journal of cancer · 2018Article
- Subclonal analysis in a lobular breast cancer with classical and solid growth pattern mimicking a solid-papillary carcinoma.The journal of pathology. Clinical research · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
When a cancer patient develops a new tumor it is necessary to determine if it is a recurrence (metastasis) of the original cancer, or an entirely new occurrence of the disease. This is accomplished by assessing the histo-pathology of the lesions. However, there are many clinical scenarios in which this pathological diagnosis is difficult. Since each tumor is characterized by a distinct pattern of somatic mutations, a more definitive diagnosis is possible in principle in these difficult clinical scenarios by comparing the two patterns. In this article we develop and evaluate a statistical strategy for this comparison when the data are derived from array copy number data, designed to identify all of the somatic allelic gains and losses across the genome. First a segmentation algorithm is used to estimate the regions of allelic gain and loss. The correlation in these patterns between the two tumors is assessed, and this is complemented with more precise quantitative comparisons of each plausibly clonal mutation within individual chromosome arms. The results are combined to determine a likelihood ratio to distinguish clonal tumor pairs (metastases) from independent second primaries. Our data analyses show that in many cases a strong clonal signal emerges. Sensitivity analyses show that most of the diagnoses are robust when the data are of high quality.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.