Evidence map›Paper›PMID 20204802›Full record

ArticleAdvances in experimental medicine and biology2010

Implantable resonators--a technique for repeated measurement of oxygen at multiple deep sites with in vivo EPR.

Hongbin Li, Huagang Hou, Artur Sucheta, Benjamin B Williams, Jean P Lariviere, Md Nadeem Khan, Piotr N Lesniewski, Bernard Gallez, Harold M Swartz

Abstract read
In one paragraph

Article in Advances in experimental medicine and biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Advances in probes and methods for clinical EPR oximetry.Advances in experimental medicine and biology · 2014
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Medical gas research
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hongbin LiEPR Center for Viable Systems, Department of Radiology, Dartmouth Medical School, 703, Vail, Hanover, NH 03755, USA.
Huagang Hou
Artur Sucheta
Benjamin B Williams
Jean P Lariviere
Md Nadeem Khan
Piotr N Lesniewski
Bernard Gallez
Harold M Swartz

Funding

Measurement of pO2 in tissues in vivo and in vitroP01EB002180 · NIBIB · DARTMOUTH COLLEGE · PI SWARTZ, HAROLD M · 2003 to 2006
$4.0M
Center for the Study of Viable SystemsP41EB002032 · NIBIB · DARTMOUTH COLLEGE · PI SWARTZ, HAROLD M · 2003 to 2005
$2.5M
NIBIB NIH HHS P01 EB002180NIBIB NIH HHS P01EB2180NIBIB NIH HHS P41 EB002032
6 · The paper itself

Abstract

EPR oximetry using implantable resonators allows measurements at much deeper sites than are possible with surface resonators (> 80 vs. 10 mm) and achieves greater sensitivity at any depth. We report here the development of an improved technique that enables us to obtain the information from multiple sites and at a variety of depths. The measurements from the various sites are resolved using a simple magnetic field gradient. In the rat brain multi-probe implanted resonators measured pO(2) at several sites simultaneously for over 6 months under normoxic, hypoxic, and hyperoxic conditions. This technique also facilitates measurements in moving parts of the animal such as the heart, because the orientation of the paramagnetic material relative to the sensing loop is not altered by the motion. The measured response is fast, enabling measurements in real time of physiological and pathological changes such as experimental cardiac ischemia in the mouse heart. The technique also is quite useful for following changes in tumor pO(2), including applications with simultaneous measurements in tumors and adjacent normal tissues.

Indexed as

AnimalsBrain NeoplasmsElectron Spin Resonance SpectroscopyMagnetic Resonance ImagingMiceMyocardial IschemiaMyocardiumOximetryOxygenRatsOxygen

Identifiers

PMID20204802
PMCPMC3806631

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.