ArticleInvestigational new drugs2011
Baicalin induces human mucoepidermoid carcinoma Mc3 cells apoptosis in vitro and in vivo.
Article in Investigational new drugs, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 43 citations in OpenAlex.
- Specific Flavonoids and Their Biosynthetic Pathway inFrontiers in plant science · 2022Review
- Challenges and future directions of potential natural products leads against 2019-nCoV outbreak.Current plant biology · 2020Review
- Baicalin alleviates collagen‑induced arthritis and suppresses TLR2/MYD88/NF‑κB p65 signaling in rats and HFLS‑RAs.Molecular medicine reports · 2020Article
- Inhibitory effect of baicalin on orthodontically induced inflammatory root resorption in rats.The Journal of international medical research · 2020Article
- A comprehensive review on phytochemistry, pharmacology, and flavonoid biosynthesis of Scutellaria baicalensis.Pharmaceutical biology · 2018Review
- Hard clam extracts induce atypical apoptosis in human gastric cancer cells.Experimental and therapeutic medicine · 2017Article
- Anti-cancer effect of Scutellaria baicalensis in combination with cisplatin in human ovarian cancer cell.BMC complementary and alternative medicine · 2017Article
- Flavonoids fromExperimental and therapeutic medicine · 2016Article
- Article
- Effects and Mechanism of Baicalin on Apoptosis of Cervical Cancer HeLa Cells I n -v itro.Iranian journal of pharmaceutical research : IJPR · 2015Article
- Cytotoxicity of dietary flavonoids on different human cancer types.Pharmacognosy reviews · 2014Review
- Chinese medicines induce cell death: the molecular and cellular mechanisms for cancer therapy.BioMed research international · 2014Review
- Ardipusilloside I induces apoptosis by regulating Bcl-2 family proteins in human mucoepidermoid carcinoma Mc3 cells.BMC complementary and alternative medicine · 2013Article
- Autophagy induced by baicalin involves downregulation of CD147 in SMMC-7721 cells in vitro.Oncology reports · 2012Article
- Comparative study of the effect of baicalin and its natural analogs on neurons with oxygen and glucose deprivation involving innate immune reaction of TLR2/TNFα.Journal of biomedicine & biotechnology · 2012Article
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Authors and funding
7 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Mucoepidermoid carcinoma (MEC) is the most common malignant tumor in salivary glands and high-grade MEC in particular demonstrates little response to chemotherapy which has been used largely for palliative treatment of metastatic disease. Baicalin, one of the main active compounds of Scutellaria baicalensis, possesses anti-inflammatory, antioxidant and antitumor properties. In the present study, we investigated the growth inhibiting and apoptosis-inducing effects of baicalin on a highly metastatic human mucoepidermoid carcinoma cell line Mc3 for the first time. Baicalin exerted dose- and time-dependent antiproliferative potential against Mc3 cells as assessed by MTT assay. Baicalin treatment of Mc3 cells resulted in an accumulation of cells at the G₀/G₁ and G₂/M phase with a concomitant decrease in cells processing to S phase as assessed by flow cytometry. Furthermore, baicalin induced apoptosis of Mc3 cells as determined by annexin V binding and PI dual staining, DNA fragmentation, nuclear condensation and in vivo tumor inhabitation. Rhodamine 123 assay indicated that baicalin caused cytotoxicity and induced apoptosis through decreasing the mitochondrial membrane potential in Mc3 cells. Our results suggest that baicalin seems to be very attractive as a new anticancer drug and a potential chemotherapeutic agent against human high-grade mucoepidermoid carcinoma.
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