ReviewSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2010
Communication and informed consent in phase 1 trials: a review of the literature from January 2005 to July 2009.
Review in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Trial
- Linguistic Strategies for Improving Informed Consent in Clinical Trials Among Low Health Literacy Patients.Journal of the National Cancer Institute · 2017Trial
- Article
- Observational
- Article
- Facilitating Informed Permission/Assent/Consent in Pediatric Clinical Trials.Paediatric drugs · 2019Article
- Do Patients With Advanced Cancer Have the Ability to Make Informed Decisions for Participation in Phase I Clinical Trials?Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2018Article
- Investigator Disclosure and Advanced Cancer Patient Understanding of Informed Consent and Prognosis in Phase I Clinical Trials.Journal of oncology practice · 2018Article
- What advanced cancer patients with limited treatment options know about clinical research: a qualitative study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017Article
- Palliative Care and Phase 1 Trials: Intervention to Improve Quality of Life and Provide Education .Clinical journal of oncology nursing · 2017Article
- Putting the "Person" in Personalized Cancer Medicine: A Systematic Review of Psychological Aspects of Targeted Therapy.Personalized medicine in oncology · 2014Article
- Strengthening the ethical assessment of placebo-controlled surgical trials: three proposals.BMC medical ethics · 2014Article
- Procedure versus process: ethical paradigms and the conduct of qualitative research.BMC medical ethics · 2012Article
- Testing the utility of a cancer clinical trial specific Question Prompt List (QPL-CT) during oncology consultations.Patient education and counseling · 2012Article
- Negotiating decisions during informed consent for pediatric Phase I oncology trials.Journal of empirical research on human research ethics : JERHRE · 2012Article
- Evaluation of an educational program to improve communication with patients about early-phase trial participation.The oncologist · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
OBJECTIVE AND
methodsA review conducted in 2005 identified many of the communication difficulties experienced by patients and doctors when discussing phase 1 (P1) oncology trials. The current paper is an update of the area and focuses on studies that measure patient comprehension of information given during the P1 trial discussion and ways to enhance understanding. A literature search was performed for relevant articles published between January 2005 and July 1st 2009.
resultsOnly 12/109 studies met the criteria for inclusion in the review. One study recorded the actual trial discussion and compared patients' understanding with what the clinician had communicated. The others used interview techniques and surveys to elicit patients' understanding of P1 trials, motivations for considering trials and expectations of benefit. Two examined interventions to aid patient understanding.
conclusionExplaining potential participation in a P1 trial with a patient with cancer is not an easy task: the doctor must ensure that the patient has an accurate understanding of their condition and that standard treatments have now been exhausted. This must be followed by admission of the probable lack of any therapeutic benefit from the P1 drug together with the possibility that there might be unwanted side effects, many of which are unknown. These are all challenging subjects. New educational initiatives informed through research conducted with patients and health care professionals are currently being developed and clearly much needed.
Indexed as
Identifiers
20204418What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.