ArticleDiabetologia2010
High normal fasting glucose level in obese youth: a marker for insulin resistance and beta cell dysregulation.
Article in Diabetologia, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 58 citations in OpenAlex.
- A Low ω-6 to ω-3 PUFA Ratio (n-6:n-3 PUFA) Diet to Treat Fatty Liver Disease in Obese Youth.The Journal of nutrition · 2020Trial
- Effect of dietary patterns differing in carbohydrate and fat content on blood lipid and glucose profiles based on weight-loss success of breast-cancer survivors.Breast cancer research : BCR · 2012Trial
- Rare variants in the melanocortin 4 receptor gene (MC4R) are associated with abdominal fat and insulin resistance in youth with obesity.International journal of obesity (2005) · 2025Article
- Nonlinear relationship between triglyceride-glucose index and the risk of prediabetes and diabetes: a secondary retrospective cohort study.Frontiers in endocrinology · 2024Article
- Associations of normal fasting glucose levels and of insulin resistance with degenerative rotator cuff tear : Normoglycemia and rotator cuff tear.BMC musculoskeletal disorders · 2023Article
- Triglyceride glucose-body mass index and the risk of progression to diabetes from prediabetes: A 5-year cohort study in Chinese adults.Frontiers in public health · 2023Article
- Promoting healthy lifestyle behaviours in youth: Findings from a novel intervention for children at risk of cardiovascular disease.Paediatrics & child health · 2021Article
- Triglyceride glucose-body mass index and the risk of diabetes: a general population-based cohort study.Lipids in health and disease · 2021Article
- Children with metabolically healthy obesity have a worse metabolic profile compared to normal-weight peers: a cross-sectional study.Endocrine · 2021Article
- Article
- High-Normal Adolescent Fasting Plasma Glucose Is Associated With Poorer Midlife Brain Health: Bogalusa Heart Study.The Journal of clinical endocrinology and metabolism · 2019Article
- Drug repurposing in alternative medicine: herbal digestive Sochehwan exerts multifaceted effects against metabolic syndrome.Scientific reports · 2019Article
- Serum ferritin level is associated with liver steatosis and fibrosis in Korean general population.Hepatology international · 2019Article
- Oxidized Derivatives of Linoleic Acid in Pediatric Metabolic Syndrome: Is Their Pathogenic Role Modulated by the Genetic Background and the Gut Microbiota?Antioxidants & redox signaling · 2019Article
- The rs626283 Variant in the MBOAT7 Gene is Associated with Insulin Resistance and Fatty Liver in Caucasian Obese Youth.The American journal of gastroenterology · 2018Article
- The rs7903146 Variant in theDiabetes care · 2017Article
- Elevated α-Hydroxybutyrate and Branched-Chain Amino Acid Levels Predict Deterioration of Glycemic Control in Adolescents.The Journal of clinical endocrinology and metabolism · 2017Article
- The Association between Pediatric NAFLD and Common Genetic Variants.Children (Basel, Switzerland) · 2017Review
- Triglycerides/glucose index is a useful surrogate marker of insulin resistance among adolescents.International journal of obesity (2005) · 2017Article
- Overweight and Obesity in Children under 5 Years: Surveillance Opportunities and Challenges for the WHO European Region.Frontiers in public health · 2017Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 3 countries.
Funding
Abstract
aims/hypothesisA high but normal fasting plasma glucose level in adults is a risk factor for future development of type 2 diabetes mellitus and cardiovascular disease. We investigated whether normal fasting plasma glucose levels (<5.60 mmol/l) are associated with decreases in insulin sensitivity and beta cell function, as well as an adverse cardiovascular profile in obese youth.
methodsWe performed a cross-sectional analysis in a multiethnic sample of 1,020 obese youth (614 girls and 406 boys; mean age 12.9 years [CI 95% 12.7-13.1], BMI z score 2.34 [CI 95% 2.31-2.38]) with normal fasting plasma glucose. All participants had a standard OGTT, with calculation of indices of insulin sensitivity and beta cell function. For the analysis, prepubertal and pubertal participants were stratified into quartiles of normal fasting plasma glucose.
resultsWe observed a significant increase in fasting insulin and AUC 2 h glucose across quartiles. Pronounced changes were observed in insulin sensitivity and secretion, particularly in the pubertal group. Moreover, the odds of presenting with impaired glucose tolerance increased by 4.5% with each 0.06 mmol/l increase in fasting plasma glucose. No significant differences in cardiovascular indices were seen across quartiles. CONCLUSIONS/
interpretationThese data suggest that in obese youth, independent of age, BMI z score, sex, family history and ethnicity, insulin sensitivity and secretion decline when moving from low to high normal fasting plasma glucose. The simple measure of fasting plasma glucose could assist clinicians in identifying children for targeted diabetes screening and subsequent lifestyle management.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.