ReviewEMBO reports2010
Differences in the DNA replication of unicellular eukaryotes and metazoans: known unknowns.
Review in EMBO reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Integrated Bioinformatic Analysis IdentifiesDisease markers · 2022Article
- Changes in soil taxonomic and functional diversity resulting from gamma irradiation.Scientific reports · 2019Article
- New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress.Nucleic acids research · 2016Article
- Balancing self-renewal against genome preservation in stem cells: How do they manage to have the cake and eat it too?Cellular and molecular life sciences : CMLS · 2016Review
- Genetic instability in budding and fission yeast-sources and mechanisms.FEMS microbiology reviews · 2015Review
- Detecting ATM-dependent chromatin modification in DNA damage response.Methods in molecular biology (Clifton, N.J.) · 2015Article
- Architecture and ssDNA interaction of the Timeless-Tipin-RPA complex.Nucleic acids research · 2014Article
- MYC and the control of DNA replication.Cold Spring Harbor perspectives in medicine · 2014Review
- Tipin functions in the protection against topoisomerase I inhibitor.The Journal of biological chemistry · 2014Article
- STAT3 interrupts ATR-Chk1 signaling to allow oncovirus-mediated cell proliferation.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Mta2 promotes Tipin-dependent maintenance of replication fork integrity.Cell cycle (Georgetown, Tex.) · 2014Article
- The cancer therapeutic potential of Chk1 inhibitors: how mechanistic studies impact on clinical trial design.British journal of clinical pharmacology · 2013Review
- Regulation of the cell division cycle in Trypanosoma brucei.Eukaryotic cell · 2012Review
- Novel regulation of checkpoint kinase 1: Is checkpoint kinase 1 a good candidate for anti-cancer therapy?Cancer science · 2012Review
- Chromatin replication and epigenome maintenance.Nature reviews. Molecular cell biology · 2012Review
- RAD51- and MRE11-dependent reassembly of uncoupled CMG helicase complex at collapsed replication forks.Nature structural & molecular biology · 2011Article
- Studies on human DNA polymerase epsilon and GINS complex and their role in DNA replication.The Journal of biological chemistry · 2011Article
- Spatiotemporally different DNA repair systems participate in Epstein-Barr virus genome maturation.Journal of virology · 2011Article
- Analysis of protein dynamics at active, stalled, and collapsed replication forks.Genes & development · 2011Article
- The DNA damage response: making it safe to play with knives.Molecular cell · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Although the basic mechanisms of DNA synthesis are conserved across species, there are differences between simple and complex organisms. In contrast to lower eukaryotes, replication origins in complex eukaryotes lack DNA sequence specificity, can be activated in response to stressful conditions and require poorly conserved factors for replication firing. The response to replication fork damage is monitored by conserved proteins, such as the TIPIN-TIM-CLASPIN complex. The absence of this complex induces severe effects on yeast replication, whereas in higher eukaryotes it is only crucial when the availability of replication origins is limiting. Finally, the dependence of DNA replication on homologous recombination proteins such as RAD51 and the MRE11-RAD50-NBS1 complex is also different; they are dispensable for yeast S-phase but essential for accurate DNA replication in metazoans under unchallenged conditions. The reasons for these differences are not yet understood. Here, we focus on some of these known unknowns of DNA replication.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.