ArticleNature protocols2010
FLOTAC: new multivalent techniques for qualitative and quantitative copromicroscopic diagnosis of parasites in animals and humans.
Article in Nature protocols, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03238131 (Comparison of Ivermectin Alone With Albendazole), which is not on this map. Cited by 190 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of Ivermectin Alone With Albendazole (ALB) Plus Ivermectin (IVM) in Their Efficacy Against Onchocerciasis
Who cites it
190 citing papers in PubMed, 4 syntheses or guidelines pooled it, 520 citations in OpenAlex.
- Systematic review of the prevalence of Gastrointestinal helminths in ruminants in Mexico.Veterinary research communications · 2025Pooled it
- Global prevalence of Ascaris infection in humans (2010-2021): a systematic review and meta-analysis.Infectious diseases of poverty · 2022Pooled it
- Status of benzimidazole resistance in intestinal nematode populations of livestock in Brazil: a systematic review.BMC veterinary research · 2017Pooled it
- Sensitivity of diagnostic tests for human soil-transmitted helminth infections: a meta-analysis in the absence of a true gold standard.International journal for parasitology · 2014Pooled it
- Disturbance in human gut microbiota networks by parasites and its implications in the incidence of depression.Scientific reports · 2020Trial
- Diagnostic comparison between FECPAKG2 and the Kato-Katz method for analyzing soil-transmitted helminth eggs in stool.PLoS neglected tropical diseases · 2018Trial
- Eprinomectin pour-on (EPRINEX® Pour-on, Merial): efficacy against gastrointestinal and pulmonary nematodes and pharmacokinetics in sheep.BMC veterinary research · 2017Trial
- Non-invasive indicators associated with the milk yield response after anthelmintic treatment at calving in dairy cows.BMC veterinary research · 2014Trial
- Efficacy and safety of nitazoxanide, albendazole, and nitazoxanide-albendazole against Trichuris trichiura infection: a randomized controlled trial.PLoS neglected tropical diseases · 2012Trial
- Nemabiome metabarcoding reveals strongyle parasite diversity in wild deer in Victoria, Australia.Parasitology research · 2026Article
- The Potential of Bioinformatics in Revolutionizing Disease Diagnosis in Sub-Saharan Africa: A Narrative Review.Health science reports · 2026Article
- Free-ranging Eurasian otter (Lutra lutra) with rare osteoblastic osteosarcoma: a forensic and genetic investigation from central Italy.BMC veterinary research · 2026Article
- Life Stage-Specific Burdens and Impacts of Gastrointestinal Nematodes in Beef Cattle in the United States: A Review of Diagnostics, Impacts on Productivity, and Immune Response.Veterinary sciences · 2026Review
- Characterizing mixed strongyle infections in foals and broodmares using cytochrome c oxidase subunit I deep amplicon sequencing.Parasites & vectors · 2026Article
- One health approach to Balantioides coli: Molecular and metabarcoding evidence of zoonotic transmission.PloS one · 2026Article
- Neglected tropical diseases: recent trends and challenges associated with its rapid diagnosis and effective therapeutic strategies.Frontiers in pharmacology · 2026Review
- Assessment of Environmental Contamination With Soil-Transmitted Helminth Eggs From Human and Animal Faeces in Southern Côte d'Ivoire: A Rapid Approach for Identifying High-Risk Communities.Journal of parasitology research · 2026Article
- Advancing gastrointestinal parasite diagnosis in West African long-legged lambs in Southern Benin: a comparative study of McMaster and Mini-FLOTAC methods.BMC veterinary research · 2025Article
- Comparing the Performance of McMaster, FLOTAC and Mini-FLOTAC Techniques in the Diagnosis of Strongylid Infections in Two Horse Populations in Portugal.Pathogens (Basel, Switzerland) · 2025Article
- Influence of Incubation Time for Viability Assessment ofPathogens (Basel, Switzerland) · 2025Article
130 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accurate diagnosis of parasitic infections is of pivotal importance for both individual patient management and population-based studies, such as drug efficacy trials and surveillance of parasitic disease control and elimination programs, in both human and veterinary public health. In this study, we present protocols for the FLOTAC basic, dual and double techniques, which are promising new multivalent, sensitive, accurate and precise methods for qualitative and quantitative copromicroscopic analysis. These various methods make use of the FLOTAC apparatus, a cylindrical device with two 5-ml flotation chambers, which allows up to 1 g of stool to be prepared for microscopic analysis. Compared with currently more widely used diagnostic methods for parasite detection in animals (e.g., McMaster and Wisconsin techniques) and humans (e.g., Kato-Katz and ether-based concentration techniques), the FLOTAC techniques show higher sensitivity and accuracy. All FLOTAC techniques can be performed on fresh fecal material as well as preserved stool samples, and require approximately 12-15 min of preparation time before microscopic analysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.