ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Prefrontal beta2 subunit-containing and alpha7 nicotinic acetylcholine receptors differentially control glutamatergic and cholinergic signaling.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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The trial behind it
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Who cites it
76 citing papers in PubMed, 132 citations in OpenAlex.
- Pharmacological Manipulation of Cortical Inhibition in the Dorsolateral Prefrontal Cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Trial
- Prefrontal cholinergic mechanisms instigating shifts from monitoring for cues to cue-guided performance: converging electrochemical and fMRI evidence from rats and humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Trial
- Modulatory effects of α7-nicotinic cholinergic receptors on perceptual sensitivity in a visual signal detection task.Psychopharmacology · 2026Article
- Choline, a nexus for neurocognitive nutrients: A narrative review.Nutrition research (New York, N.Y.) · 2026Review
- Article
- Quantitative Systems Pharmacology Development and Application in Neuroscience.Handbook of experimental pharmacology · 2025Review
- Cortico-striatal action control inherent of opponent cognitive-motivational styles.bioRxiv : the preprint server for biology · 2024Article
- Distinct cholinergic circuits underlie discrete effects of reward on attention.Frontiers in molecular neuroscience · 2024Review
- MProceedings of the National Academy of Sciences of the United States of America · 2023Article
- A Novel Biomarker of Neuronal Glutamate Metabolism in Nonhuman Primates Using LocalizedBiological psychiatry. Cognitive neuroscience and neuroimaging · 2022Article
- Chemogenetic inhibition of prefrontal projection neurons constrains top-down control of attention in young but not aged rats.Brain structure & function · 2021Article
- Make a Left Turn: Cortico-Striatal Circuitry Mediating the Attentional Control of Complex Movements.Movement disorders : official journal of the Movement Disorder Society · 2021Review
- Paternal nicotine enhances fear memory, reduces nicotine administration, and alters hippocampal genetic and neural function in offspring.Addiction biology · 2021Article
- Nicotinic Acetylcholine Receptor α7 Subunit Is an Essential Regulator of Seizure Susceptibility.Frontiers in neurology · 2021Article
- The role of acetylcholine in negative encoding bias: Too much of a good thing?The European journal of neuroscience · 2021Review
- Cognitive rigidity and BDNF-mediated frontostriatal glutamate neuroadaptations during spontaneous nicotine withdrawal.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Does kynurenic acid act on nicotinic receptors? An assessment of the evidence.Journal of neurochemistry · 2020Review
- Forebrain Cholinergic Signaling: Wired and Phasic, Not Tonic, and Causing Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Review
- Cholinergic Signaling Dynamics and Cognitive Control of Attention.Current topics in behavioral neurosciences · 2020Review
- Dystonia and levodopa-induced dyskinesias in Parkinson's disease: Is there a connection?Neurobiology of disease · 2019Review
16 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
One-second-long increases in prefrontal cholinergic activity ("transients") were demonstrated previously to be necessary for the incorporation of cues into ongoing cognitive processes ("cue detection"). Nicotine and, more robustly, selective agonists at alpha4beta2* nicotinic acetylcholine receptors (nAChRs) enhance cue detection and attentional performance by augmenting prefrontal cholinergic activity. The present experiments determined the role of beta2-containing and alpha7 nAChRs in the generation of prefrontal cholinergic and glutamatergic transients in vivo. Transients were evoked by nicotine, the alpha4beta2* nAChR agonist ABT-089 [2-methyl-3-(2-(S)-pyrrolindinylmethoxy) pyridine dihydrochloride], or the alpha7 nAChR agonist A-582941 [2-methyl-5-(6-phenyl-pyridazin-3-yl)-octahydro-pyrrolo[3,4-c]pyrrole]. Transients were recorded in mice lacking beta2 or alpha7 nAChRs and in rats after removal of thalamic glutamatergic or midbrain dopaminergic inputs to prefrontal cortex. The main results indicate that stimulation of alpha4beta2* nAChRs evokes glutamate release and that the presence of thalamic afferents is necessary for the generation of cholinergic transients. ABT-089-evoked transients were completely abolished in mice lacking beta2* nAChRs. The amplitude, but not the decay rate, of nicotine-evoked transients was reduced by beta2* knock-out. Conversely, in mice lacking the alpha7 nAChR, the decay rate, but not the amplitude, of nicotine-evoked cholinergic and glutamatergic transients was attenuated. Substantiating the role of alpha7 nAChR in controlling the duration of release events, stimulation of alpha7 nAChR produced cholinergic transients that lasted 10- to 15-fold longer than those evoked by nicotine. alpha7 nAChR-evoked cholinergic transients are mediated in part by dopaminergic activity. Prefrontal alpha4beta2* nAChRs play a key role in evoking and facilitating the transient glutamatergic-cholinergic interactions that are necessary for cue detection and attentional performance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.