ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Differential plasticity of the GABAergic and glycinergic synaptic transmission to rat lumbar motoneurons after spinal cord injury.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04807764 (Priming With High-Frequency Trans-spinal Stimulation to Augment Locomotor Benefits in Spinal Cord Injury), which is not on this map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Priming With High-Frequency Trans-spinal Stimulation to Augment Locomotor Benefits in Spinal Cord Injury
Who cites it
22 citing papers in PubMed.
- KCC2 phosphorylation dynamics relate to oligomerization during development and after spinal cord injury.Frontiers in molecular neuroscience · 2026Article
- Review
- Transspinal stimulation preceding assisted step training reorganizes neuronal excitability and function of inhibitory networks in spinal cord injury: a randomized controlled trial.Frontiers in neurology · 2025Article
- Plastic Events of the Vestibular Nucleus: the Initiation of Central Vestibular Compensation.Molecular neurobiology · 2024Review
- Plasticity in Motoneurons Following Spinal Cord Injury in Fructose-induced Diabetic Rats.Journal of molecular neuroscience : MN · 2022Article
- How Does the Central Nervous System for Posture and Locomotion Cope With Damage-Induced Neural Asymmetry?Frontiers in systems neuroscience · 2022Review
- GABAergic Mechanisms Can Redress the Tilted Balance between Excitation and Inhibition in Damaged Spinal Networks.Molecular neurobiology · 2021Review
- BDNF Signaling Promotes Vestibular Compensation by Increasing Neurogenesis and Remodeling the Expression of Potassium-Chloride Cotransporter KCC2 and GABAA Receptor in the Vestibular Nuclei.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Histamine 1 receptor-Gβγ-cAMP/PKA-CFTR pathway mediates the histamine-induced resetting of the suprachiasmatic circadian clock.Molecular brain · 2016Article
- A Review on Locomotor Training after Spinal Cord Injury: Reorganization of Spinal Neuronal Circuits and Recovery of Motor Function.Neural plasticity · 2016Review
- Locomotor training improves reciprocal and nonreciprocal inhibitory control of soleus motoneurons in human spinal cord injury.Journal of neurophysiology · 2015Article
- Serotonergic modulation of post-synaptic inhibition and locomotor alternating pattern in the spinal cord.Frontiers in neural circuits · 2014Review
- Inhibitory glycinergic neurotransmission in the mammalian auditory brainstem upon prolonged stimulation: short-term plasticity and synaptic reliability.Frontiers in neural circuits · 2014Article
- Sodium-mediated plateau potentials in lumbar motoneurons of neonatal rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Selective effects of baclofen on use-dependent modulation of GABAB inhibition after tetraplegia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- The impact of discrete modes of spinal cord injury on bladder muscle contractility.BMC urology · 2013Article
- Activation of 5-HT2A receptors upregulates the function of the neuronal K-Cl cotransporter KCC2.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Prenatal exposure to fenugreek impairs sensorimotor development and the operation of spinal cord networks in mice.PloS one · 2013Article
- A neonatal mouse spinal cord injury model for assessing post-injury adaptive plasticity and human stem cell integration.PloS one · 2013Article
- Modulation of inhibitory strength and kinetics facilitates regulation of persistent inward currents and motoneuron excitability following spinal cord injury.Journal of neurophysiology · 2011Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maturation of inhibitory postsynaptic transmission onto motoneurons in the rat occurs during the perinatal period, a time window during which pathways arising from the brainstem reach the lumbar enlargement of the spinal cord. There is a developmental switch in miniature IPSCs (mIPSCs) from predominantly long-duration GABAergic to short-duration glycinergic events. We investigated the effects of a complete neonatal [postnatal day 0 (P0)] spinal cord transection (SCT) on the expression of Glycine and GABA(A) receptor subunits (GlyR and GABA(A)R subunits) in lumbar motoneurons. In control rats, the density of GlyR increased from P1 to P7 to reach a plateau, whereas that of GABA(A)R subunits dropped during the same period. In P7 animals with neonatal SCT (SCT-P7), the GlyR densities were unchanged compared with controls of the same age, while the developmental downregulation of GABA(A)R was prevented. Whole-cell patch-clamp recordings of mIPSCs performed in lumbar motoneurons at P7 revealed that the decay time constant of miniature IPSCs and the proportion of GABAergic events significantly increased after SCT. After daily injections of the 5-HT(2)R agonist DOI, GABA(A)R immunolabeling on SCT-P7 motoneurons dropped down to values reported in control-P7, while GlyR labeling remained stable. A SCT made at P5 significantly upregulated the expression of GABA(A)R 1 week later with little, if any, influence on GlyR. We conclude that the plasticity of GlyR is independent of supraspinal influences whereas that of GABA(A)R is markedly influenced by descending pathways, in particular serotoninergic projections.
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