ArticleAJNR. American journal of neuroradiology2010
White matter characteristics and cognition in prenatally opiate- and polysubstance-exposed children: a diffusion tensor imaging study.
Article in AJNR. American journal of neuroradiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 3 of them syntheses that pooled it.
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Who cites it
46 citing papers in PubMed, 3 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Impact of prenatal tobacco exposure on brain structure and function in offspring: a systematic review and meta-analysis of MRI findings.Neuroradiology · 2025Pooled it
- Birth, cognitive and behavioral effects of intrauterine cannabis exposure in infants and children: A systematic review and meta-analysis.Addiction (Abingdon, England) · 2024Pooled it
- Maternal Use of Opioids During Pregnancy and Congenital Malformations: A Systematic Review.Pediatrics · 2017Pooled it
- Limbic System Microstructure in Neonates With Antenatal Opioid Exposure.JAMA network open · 2026Article
- Animal Models of Prenatal Opioid Exposure: Insights into Impaired Neurodevelopment.Advances in experimental medicine and biology · 2026Review
- Fetal brain volumes and brain gyrification index associated with opioid exposure.Brain communications · 2026Article
- A human iPSC-derived midbrain neural stem cell model of prenatal opioid exposure and withdrawal: A proof of concept study.PloS one · 2025Article
- Methadone directly impairs central nervous system cells in vitro.Scientific reports · 2024Article
- Fetal and Infant Effects of Maternal Opioid Use during Pregnancy: A Literature Review including Clinical, Toxicological, Pharmacogenomic, and Epigenetic Aspects for Forensic Evaluation.Children (Basel, Switzerland) · 2024Review
- A Prospective Multi-Institutional Study Comparing the Brain Development in the Third Trimester between Opioid-Exposed and Nonexposed Fetuses Using Advanced Fetal MR Imaging Techniques.AJNR. American journal of neuroradiology · 2024Article
- DTI of Opioid-Exposed Fetuses Using ComBat Harmonization: A Bi-Institutional Study.AJNR. American journal of neuroradiology · 2023Article
- Prenatal heroin exposure alters brain morphology and connectivity in adolescent mice.NMR in biomedicine · 2023Article
- Prenatal exposure to opioids and neurodevelopment in infancy and childhood: A systematic review.Frontiers in pediatrics · 2023Review
- Article
- Alterations of brain microstructures in a mouse model of prenatal opioid exposure detected by diffusion MRI.Scientific reports · 2022Article
- An intergenerational lifespan perspective on the neuroscience of prenatal substance exposure.Pharmacology, biochemistry, and behavior · 2022Article
- Perinatal methadone exposure attenuates myelination and induces oligodendrocyte apoptosis in neonatal rat brain.Experimental biology and medicine (Maywood, N.J.) · 2022Article
- Methadone alters the peripheral inflammatory and central immune landscape following prenatal exposure in rats.Advances in drug and alcohol research · 2022Article
- Brain structural connectome in neonates with prenatal opioid exposure.Frontiers in neuroscience · 2022Article
- Understanding the effects of opioids vs non-opioids in the treatment of neonatal abstinence syndrome, an in vitro model.Frontiers in pediatrics · 2022Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposePrenatal drug exposure may influence the developing brain. Our aim was to study WM characteristics with DTI in children with prenatal opiate and polysubstance exposure and in controls. We assessed whether group differences in FA, DA, and DR could be found and related to cognitive function. MATERIALS AND
methodsThe study was approved by a committee for medical research ethics. Parents signed an informed consent; children gave spoken consent. Our sample included 14 prenatally substance-exposed adopted children (5 girls; age range, 8.6-13.9 years; mean, 11.3 +/- 1.7 years) and 14 control children (7 girls; age range, 9.0-10.2 years; mean, 9.8 +/- 0.3 years). Tract-based spatial statistics were used to define a common WM skeleton for the sample, and FA was compared between groups throughout the skeleton, controlling for age and sex. Clusters of significant group differences >or=100 voxels (P <. 05) were identified. FA, DA, and DR within clusters were correlated with cognitive function.
resultsTen clusters of FA group differences, mostly in central, posterior, and inferior parts of the brain, were identified (P <. 05), showing lower FA in substance-exposed children. FA and DA correlated positively and DR, negatively with cognitive function across groups.
conclusionsPrenatally substance-exposed children exhibited lower FA in restricted areas of WM, mostly relatively central, inferior, and posterior, where myelination occurs early in development. Myelin in these areas may be particularly vulnerable to prenatal substance exposure. FA and DR related moderately to cognitive function. Potential confounding factors existed and were considered.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.