ArticleThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2010
Reversal of impaired myocardial beta-adrenergic receptor signaling by continuous-flow left ventricular assist device support.
Article in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 37 citations in OpenAlex.
- Physiologic effects of different hemodynamic patterns of LVAD.Frontiers in cardiovascular medicine · 2025Review
- Predictors of long-term success after successful explantation of continuous flow left ventricular assist device support.Interdisciplinary cardiovascular and thoracic surgery · 2024Article
- Left ventricular assist device explantation using a new double-patch technique†.Interdisciplinary cardiovascular and thoracic surgery · 2023Article
- Myocardial Recovery.Diagnostics (Basel, Switzerland) · 2023Review
- Myocardial recovery evaluation from ventricular assist device in patients with dilated cardiomyopathy.ESC heart failure · 2022Article
- Left ventricular reverse remodelling and its predictors in non-ischaemic cardiomyopathy.ESC heart failure · 2022Review
- Reverse Remodeling With Left Ventricular Assist Devices.Circulation research · 2021Review
- Hurdles to Cardioprotection in the Critically Ill.International journal of molecular sciences · 2019Review
- Novel Molecular Approaches in Heart Failure: Seven Trans-Membrane Receptors Signaling in the Heart and Circulating Blood Leukocytes.Frontiers in cardiovascular medicine · 2015Review
- Myocardial recovery during mechanical circulatory support: cellular, molecular, genomic and organ levels.Heart, lung and vessels · 2015Article
- G protein-coupled receptor kinase 2: a link between myocardial contractile function and cardiac metabolism.Circulation research · 2014Review
- Assessment of myocardial viability and left ventricular function in patients supported by a left ventricular assist device.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2014Article
- Targeting GRK2 by gene therapy for heart failure: benefits above β-blockade.Gene therapy · 2012Review
- G protein coupled receptor kinases as therapeutic targets in cardiovascular disease.Circulation research · 2011Review
- betaARKct: a therapeutic approach for improved adrenergic signaling and function in heart disease.Journal of cardiovascular translational research · 2010Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundMyocardial beta-adrenergic receptor (beta-AR) signaling is severely impaired in chronic heart failure (HF). This study was conducted to determine if left ventricular (LV) beta-AR signaling could be restored after continuous-flow LV assist device (LVAD) support.
methodsTwelve patients received LVADs as a bridge to transplant. Paired LV biopsy specimens were obtained at the time of LVAD implant (HF group) and transplant (LVAD group). The mean duration of LVAD support was 152 +/- 34 days. Myocardial beta-AR signaling was assessed by measuring adenylyl cyclase (AC) activity, total beta-AR density (B(max)), and G protein-coupled receptor kinase-2 (GRK2) expression and activity. LV specimens from 8 non-failing hearts (NF) were used as controls.
resultsBasal and isoproterenol-stimulated AC activity was significantly lower in HF vs NF, indicative of beta-AR uncoupling. Continuous-flow LVAD support restored basal and isoproterenol-stimulated AC activity to levels similar to NF. B(max) was decreased in HF vs NF and increased to nearly normal in the LVAD group. GRK2 expression was increased 2.6-fold in HF vs NF and was similar to NF after LVAD support. GRK2 activity was 3.2-fold greater in HF vs NF and decreased to NF levels in the LVAD group.
conclusionsMyocardial beta-AR signaling can be restored to nearly normal after continuous-flow LVAD support. This is similar to previous data for volume-displacement pulsatile LVADs. Decreased GRK2 activity is an important mechanism and indicates that normalization of the neurohormonal milieu associated with HF is similar between continuous-flow and pulsatile LVADs. This may have important implications for myocardial recovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.