ArticleJournal of controlled release : official journal of the Controlled Release Society2010
Ultrasound-enhanced delivery of targeted echogenic liposomes in a novel ex vivo mouse aorta model.
Article in Journal of controlled release : official journal of the Controlled Release Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed.
- Intranasal vs. Device-Assisted Drug Delivery: Advantages and Limitations for the Delivery of Biopharmaceuticals to the CNS.Pharmaceutics · 2026Review
- Physical Characterization to Improve Scalability and Potential of Anesthetic-Loaded Nanodroplets.Pharmaceutics · 2023Article
- Recent Advances in Liposomal-Based Anti-Inflammatory Therapy.Pharmaceutics · 2021Review
- Current advances in ultrasound-combined nanobubbles for cancer-targeted therapy: a review of the current status and future perspectives.RSC advances · 2021Review
- Near-infrared fluorescence imaging-guided focused ultrasound-mediated therapy against Rheumatoid Arthritis by MTX-ICG-loaded iRGD-modified echogenic liposomes.Theranostics · 2020Article
- [Efficacy of internalized RGD-modified echogenic liposomes in diagnosis and treatment in a mouse model of rheumatoid arthritis].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2017Article
- Delivery of bevacizumab to atheromatous porcine carotid tissue using echogenic liposomes.Drug delivery · 2016Article
- Targeted Ultrasound-Assisted Cancer-Selective Chemical Labeling and Subsequent Cancer Imaging using Click Chemistry.Angewandte Chemie (International ed. in English) · 2016Article
- Trans-Stent B-Mode Ultrasound and Passive Cavitation Imaging.Ultrasound in medicine & biology · 2016Article
- Ultrasound-enhanced bevacizumab release from echogenic liposomes for inhibition of atheroma progression.Journal of liposome research · 2016Article
- Intra-Arterial Drug and Light Delivery for Photodynamic Therapy Using Visudyne®: Implication for Atherosclerotic Plaque Treatment.Frontiers in physiology · 2016Article
- Sonothrombolysis.Advances in experimental medicine and biology · 2016Review
- Loss of echogenicity and onset of cavitation from echogenic liposomes: pulse repetition frequency independence.Ultrasound in medicine & biology · 2015Article
- Microfluidic remote loading for rapid single-step liposomal drug preparation.Lab on a chip · 2014Article
- Nitric oxide pretreatment enhances atheroma component highlighting in vivo with intercellular adhesion molecule-1-targeted echogenic liposomes.Ultrasound in medicine & biology · 2014Article
- Real-time vascular mechanosensation through ex vivo artery perfusion.Biological procedures online · 2014Article
- Broadband attenuation measurements of phospholipid-shelled ultrasound contrast agents.Ultrasound in medicine & biology · 2014Article
- Tissue plasminogen activator-based clot busting: Controlled delivery approaches.Global cardiology science & practice · 2014Review
- Prediction and suppression of HIFU-induced vessel rupture using passive cavitation detection in an ex vivo model.Journal of therapeutic ultrasound · 2014Article
- Nitric oxide improves molecular imaging of inflammatory atheroma using targeted echogenic immunoliposomes.Atherosclerosis · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
The goal of this study was to determine whether targeted, Rhodamine-labeled echogenic liposomes (Rh-ELIP) containing nanobubbles could be delivered to the arterial wall, and whether 1-MHz continuous wave ultrasound would enhance this delivery profile. Aortae excised from apolipoprotein-E-deficient (n=8) and wild-type (n=8) mice were mounted in a pulsatile flow system through which Rh-ELIP were delivered in a stream of bovine serum albumin. Half the aortae from each group were treated with 1-MHz continuous wave ultrasound at 0.49 MPa peak-to-peak pressure, and half underwent sham exposure. Ultrasound parameters were chosen to promote stable cavitation and avoid inertial cavitation. A broadband hydrophone was used to monitor cavitation activity. After treatment, aortic sections were prepared for histology and analyzed by an individual blinded to treatment conditions. Delivery of Rh-ELIP to the vascular endothelium was observed, and sub-endothelial penetration of Rh-ELIP was present in five of five ultrasound-treated aortae and was absent in those not exposed to ultrasound. However, the degree of penetration in the ultrasound-exposed aortae was variable. There was no evidence of ultrasound-mediated tissue damage in any specimen. Ultrasound-enhanced delivery within the arterial wall was demonstrated in this novel model, which allows quantitative evaluation of therapeutic delivery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.