ArticleEmerging infectious diseases2010
Vaccine preventability of meningococcal clone, Greater Aachen Region, Germany.
Article in Emerging infectious diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Increase of invasive meningococcal serogroup W disease in Europe, 2013 to 2017.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2019Observational
- Article
- Genetic characteristics of Neisseria meningitidis serogroup B strains carried by adolescents living in Milan, Italy: implications for vaccine efficacy.Human vaccines & immunotherapeutics · 2013Article
- Genetic distribution of noncapsular meningococcal group B vaccine antigens in Neisseria lactamica.Clinical and vaccine immunology : CVI · 2013Article
- Automated extraction of typing information for bacterial pathogens from whole genome sequence data: Neisseria meningitidis as an exemplar.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2013Review
- An analysis of the sequence variability of meningococcal fHbp, NadA and NHBA over a 50-year period in the Netherlands.PloS one · 2013Article
- Geotemporal analysis of Neisseria meningitidis clones in the United States: 2000-2005.PloS one · 2013Article
- Ion torrent personal genome machine sequencing for genomic typing of Neisseria meningitidis for rapid determination of multiple layers of typing information.Journal of clinical microbiology · 2012Article
- Consensus recommendation for meningococcal disease prevention in children and adolescents in the Middle East region.Journal of epidemiology and global health · 2012Review
- Persistence of hyperinvasive meningococcal strain types during global spread as recorded in the PubMLST database.PloS one · 2012Article
- Opc expression, LPS immunotype switch and pilin conversion contribute to serum resistance of unencapsulated meningococci.PloS one · 2012Article
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Emergence of serogroup B meningococci of clonal complex sequence type (ST) 41/44 can cause high levels of disease, as exemplified by a recent epidemic in New Zealand. Multiplication of annual incidence rates (3.1 cases/100,000 population) of meningococcal disease in a defined German region, the city of Aachen and 3 neighboring countries (Greater Aachen) prompted us to investigate and determine the source and nature of this outbreak. Using molecular typing and geographic mapping, we analyzed 1,143 strains belonging to ST41/44 complex, isolated from persons with invasive meningococcal disease over 6 years (2001-2006) from 2 German federal states (total population 26 million) and the Netherlands. A spatially slowly moving clone with multiple-locus variable-number tandem repeat analysis type 19, ST42, and antigenic profile B:P1.7-2,4:F1-5 was responsible for the outbreak. Bactericidal activity in serum samples from the New Zealand MeNZB vaccination campaign confirmed vaccine preventability. Because this globally distributed epidemic strain spreads slowly, vaccination efforts could possibly eliminate meningococcal disease in this area.
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