SynthesisThe British journal of general practice : the journal of the Royal College of General Practitioners2010
Validity of diagnostic coding within the General Practice Research Database: a systematic review.
Synthesis in The British journal of general practice : the journal of the Royal College of General Practitioners, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 348 papers, 9 of them syntheses that pooled it.
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Who cites it
348 citing papers in PubMed, 9 syntheses or guidelines pooled it.
- Five comparative cohorts to assess the risk of genital tract infections associated with sodium-glucose cotransporter-2 inhibitors initiation in type 2 diabetes mellitus.Diabetic medicine : a journal of the British Diabetic Association · 2022Pooled it
- Comparative risk of acute myocardial infarction for anti-osteoporosis drugs in primary care: a meta-analysis of propensity-matched cohort findings from the UK Clinical Practice Research Database and the Catalan SIDIAP Database.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Pooled it
- Renal effectiveness and safety of the sodium-glucose cotransporter-2 inhibitors: a population-based cohort study.BMJ open diabetes research & care · 2021Pooled it
- Key Characteristics of Database Studies on Drug Effectiveness in the Postmarketing Stage: A Systematic Review.Pharmaceutical medicine · 2021Pooled it
- Identification of mental health and quality of life outcomes in primary care databases in the UK: a systematic review.BMJ open · 2019Pooled it
- Weight loss as a predictor of cancer in primary care: a systematic review and meta-analysis.The British journal of general practice : the journal of the Royal College of General Practitioners · 2018Pooled it
- Venous thromboembolism and mortality in breast cancer: cohort study with systematic review and meta-analysis.BMC cancer · 2017Pooled it
- Factors influencing the development of primary care data collection projects from electronic health records: a systematic review of the literature.BMC medical informatics and decision making · 2017Pooled it
- Polymyalgia rheumatica and risk of coronary artery disease: a systematic review and meta-analysis of observational studies.Rheumatology international · 2017Pooled it
- Observational
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- Consultations with locum doctors in UK general practice: longitudinal analysis of electronic health records.The British journal of general practice : the journal of the Royal College of General Practitioners · 2026Article
- Trends in first-line monotherapy and combination therapy for hypertension in UK primary care.British journal of clinical pharmacology · 2026Article
- Taking a closer look: Can an app improve diagnostic accuracy in urgent care? Cluster-randomized interventional trial DASI.PLOS digital health · 2026Article
- The incidence rates and prevalence of treated glaucoma in the United Kingdom, 2000-2022.PloS one · 2026Article
- Characterising intra-articular corticosteroid injections use in UK primary care: a retrospective cohort study between 2005 and 2020.Rheumatology advances in practice · 2026Article
- Why NHS hospital co-morbidity research may be wrong: how clinical coding fails to identify the impact of diabetes mellitus on cancer survival.British journal of cancer · 2025Observational
- RecUrrent Intra-articular Corticosteroid injections in Osteoarthritis: the RUbICOn mixed-methods study.Health technology assessment (Winchester, England) · 2025Article
288 more citing papers are in PubMed but not listed here.
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Funding
Abstract
backgroundThe UK-based General Practice Research Database (GPRD) is a valuable source of longitudinal primary care records and is increasingly used for epidemiological research.
aimTo conduct a systematic review of the literature on accuracy and completeness of diagnostic coding in the GPRD. DESIGN OF STUDY: Systematic review.
methodSix electronic databases were searched using search terms relating to the GPRD, in association with terms synonymous with validity, accuracy, concordance, and recording. A positive predictive value was calculated for each diagnosis that considered a comparison with a gold standard. Studies were also considered that compared the GPRD with other databases and national statistics.
resultsA total of 49 papers are included in this review. Forty papers conducted validation of a clinical diagnosis in the GPRD. When assessed against a gold standard (validation using GP questionnaire, primary care medical records, or hospital correspondence), most of the diagnoses were accurately recorded in the patient electronic record. Acute conditions were not as well recorded, with positive predictive values lower than 50%. Twelve papers compared prevalence or consultation rates in the GPRD against other primary care databases or national statistics. Generally, there was good agreement between disease prevalence and consultation rates between the GPRD and other datasets; however, rates of diabetes and musculoskeletal conditions were underestimated in the GPRD.
conclusionMost of the diagnoses coded in the GPRD are well recorded. Researchers using the GPRD may want to consider how well the disease of interest is recorded before planning research, and consider how to optimise the identification of clinical events.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.