ArticleJournal of neuroinflammation2010
Membrane attack complex inhibitor CD59a protects against focal cerebral ischemia in mice.
Article in Journal of neuroinflammation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 58 citations in OpenAlex.
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- Predictive value of soluble CD59 for poor 28-day neurological prognosis and all-cause mortality in patients after cardiopulmonary resuscitation: a prospective observatory study.Journal of intensive care · 2023Article
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- Placental proteins with predicted roles in fetal development decrease in premature infants.Pediatric research · 2022Article
- Soluble terminal complement activation fragment sC5b-9: a new serum biomarker for traumatic brain injury?European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2021Observational
- The innate immune system in diabetic retinopathy.Progress in retinal and eye research · 2021Review
- Aberrant Complement System Activation in Neurological Disorders.International journal of molecular sciences · 2021Review
- Transplantation of hPSC-derived pericyte-like cells promotes functional recovery in ischemic stroke mice.Nature communications · 2020Article
- MiR-34a Interacts with Cytochrome c and Shapes Stroke Outcomes.Scientific reports · 2020Article
- Salidroside Restores an Anti-inflammatory Endothelial Phenotype by Selectively Inhibiting Endothelial Complement After Oxidative Stress.Inflammation · 2020Article
- Significance of Complement System in Ischemic Stroke: A Comprehensive Review.Aging and disease · 2019Review
- Roles of Specialized Pro-Resolving Lipid Mediators in Cerebral Ischemia Reperfusion Injury.Frontiers in neurology · 2018Review
- Article
- Injury site-specific targeting of complement inhibitors for treating stroke.Immunological reviews · 2016Review
- Article
- Mitochondrial Impairment in Cerebrovascular Endothelial Cells is Involved in the Correlation between Body Temperature and Stroke Severity.Aging and disease · 2016Article
- Knockout of silent information regulator 2 (SIRT2) preserves neurological function after experimental stroke in mice.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2015Article
- Mitochondrial crisis in cerebrovascular endothelial cells opens the blood-brain barrier.Stroke · 2015Article
- Complement in the Homeostatic and Ischemic Brain.Frontiers in immunology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe complement system is a crucial mediator of inflammation and cell lysis after cerebral ischemia. However, there is little information about the exact contribution of the membrane attack complex (MAC) and its inhibitor-protein CD59.
methodsTransient focal cerebral ischemia was induced by middle cerebral artery occlusion (MCAO) in young male and female CD59a knockout and wild-type mice. Two models of MCAO were applied: 60 min MCAO and 48 h reperfusion, as well as 30 min MCAO and 72 h reperfusion. CD59a knockout animals were compared to wild-type animals in terms of infarct size, edema, neurological deficit, and cell death. RESULTS AND DISCUSSION: CD59a-deficiency in male mice caused significantly increased infarct volumes and brain swelling when compared to wild-type mice at 72 h after 30 min-occlusion time, whereas no significant difference was observed after 1 h-MCAO. Moreover, CD59a-deficient mice had impaired neurological function when compared to wild-type mice after 30 min MCAO.
conclusionWe conclude that CD59a protects against ischemic brain damage, but depending on the gender and the stroke model used.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.