ArticleBMC veterinary research2010
Monitoring of clinical signs in goats with transmissible spongiform encephalopathies.
Article in BMC veterinary research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- Improving Clinical Diagnosis of Transmissible Spongiform Encephalopathies in Sheep: Which Signs Are Important?Animals : an open access journal from MDPI · 2025Article
- Article
- Differential Accumulation of Misfolded Prion Strains in Natural Hosts of Prion Diseases.Viruses · 2021Review
- Goats naturally devoid of PrPVeterinary research · 2020Article
- The Scrapie Prevalence in a Goat Herd Is Underestimated by Using a Rapid Diagnostic Test.Frontiers in bioengineering and biotechnology · 2020Article
- Evaluation of Antemortem Diagnostic Techniques in Goats Naturally Infected With Scrapie.Frontiers in veterinary science · 2020Article
- Classical Scrapie Did Not Re-occur in Goats After Cleaning and Disinfection of the Farm Premises.Frontiers in veterinary science · 2020Article
- Clinical, pathological, and molecular features of classical and L-type atypical-BSE in goats.PloS one · 2018Article
- Article
- Effect of Polymorphisms at Codon 146 of the Goat PRNP Gene on Susceptibility to Challenge with Classical Scrapie by Different Routes.Journal of virology · 2017Article
- Genetic resistance to transmissible spongiform encephalopathies (TSE) in goats.EFSA journal. European Food Safety Authority · 2017Article
- Codon 141 polymorphisms of the ovine prion protein gene affect the phenotype of classical scrapie transmitted from goats to sheep.BMC veterinary research · 2017Article
- Evidence of scrapie transmission to sheep via goat milk.BMC veterinary research · 2016Article
- Abnormalities in Brainstem Auditory Evoked Potentials in Sheep with Transmissible Spongiform Encephalopathies and Lack of a Clear Pathological Relationship.Frontiers in veterinary science · 2016Article
- The placenta shed from goats with classical scrapie is infectious to goat kids and lambs.The Journal of general virology · 2015Article
- Further characterisation of transmissible spongiform encephalopathy phenotypes after inoculation of cattle with two temporally separated sources of sheep scrapie from Great Britain.BMC research notes · 2015Article
- The pathological and molecular but not clinical phenotypes are maintained after second passage of experimental atypical bovine spongiform encephalopathy in cattle.BMC veterinary research · 2014Article
- Clinical examination protocol to detect atypical and classical scrapie in sheep.Journal of visualized experiments : JoVE · 2014Article
- Evidence of effective scrapie transmission via colostrum and milk in sheep.BMC veterinary research · 2013Article
- Experimental H-type and L-type bovine spongiform encephalopathy in cattle: observation of two clinical syndromes and diagnostic challenges.BMC veterinary research · 2012Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAs there is limited information about the clinical signs of BSE and scrapie in goats, studies were conducted to describe the clinical progression of scrapie and BSE in goats and to evaluate a short clinical protocol for its use in detecting scrapie-affected goats in two herds with previously confirmed scrapie cases. Clinical assessments were carried out in five goats intracerebrally infected with the BSE agent as well as five reported scrapie suspects and 346 goats subject to cull from the two herds, 24 of which were retained for further monitoring. The brain and selected lymphoid tissue were examined by postmortem tests for disease confirmation.
resultsThe sensitivity and specificity of the short clinical protocol in detecting a scrapie case in the scrapie-affected herds was 3.9% and 99.6%, respectively, based on the presence of tremor, positive scratch test, extensive hair loss, ataxia and absent menace response. All BSE- and scrapie-affected goats displayed abnormalities in sensation (over-reactivity to external stimuli, startle responses, pruritus, absent menace response) and movement (ataxia, tremor, postural deficits) at an advanced clinical stage but the first detectable sign associated with scrapie or BSE could vary between animals. Signs of pruritus were not always present despite similar prion protein genotypes. Clinical signs of scrapie were also displayed by two scrapie cases that presented with detectable disease-associated prion protein only in lymphoid tissues.
conclusionsBSE and scrapie may present as pruritic and non-pruritic forms in goats. Signs assessed for the clinical diagnosis of scrapie or BSE in goats should include postural and gait abnormalities, pruritus and visual impairment. However, many scrapie cases will be missed if detection is solely based on the display of clinical signs. PrPd accumulation in the brain appeared to be related to the severity of clinical disease but not to the display of individual neurological signs.
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