ArticleImmunology2010
Salmonella pathogenicity island 1 differentially modulates bacterial entry to dendritic and non-phagocytic cells.
Article in Immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Mechanisms conferring multi-layered protection against intestinal Salmonella Typhimurium infection.FEMS microbiology reviews · 2025Review
- Structural investigation on SPI-6-associated Salmonella typhimurium VirG-like stress protein that promotes pathogen survival in macrophages.Protein science : a publication of the Protein Society · 2022Article
- The Hha-TomB toxin-antitoxin module in Salmonella enterica serovar Typhimurium limits its intracellular survival profile and regulates host immune response.Cell biology and toxicology · 2022Article
- Harmine, an inhibitor of the type III secretion system ofFrontiers in cellular and infection microbiology · 2022Article
- Murine AML12 hepatocytes allow Salmonella Typhimurium T3SS1-independent invasion and intracellular fate.Scientific reports · 2021Article
- Article
- Zinc-dependent substrate-level phosphorylation powers Salmonella growth under nitrosative stress of the innate host response.PLoS pathogens · 2018Article
- PersistentFrontiers in immunology · 2018Article
- Epithelial Cell Damage Activates Bactericidal/Permeability Increasing-Protein (BPI) Expression in Intestinal Epithelium.Frontiers in microbiology · 2017Article
- Interleukin-10 Production by T and B Cells Is a Key Factor to Promote SystemicFrontiers in immunology · 2017Article
- Article
- Relevant Genes Linked to Virulence Are Required for Salmonella Typhimurium to Survive Intracellularly in the Social Amoeba Dictyostelium discoideum.Frontiers in microbiology · 2016Article
- Article
- Article
- Salmonella pathogenicity island 1(SPI-1) at work.Current microbiology · 2013Review
- Cytosporone B, an inhibitor of the type III secretion system of Salmonella enterica serovar Typhimurium.Antimicrobial agents and chemotherapy · 2013Article
- Interactions of Salmonella enterica with dendritic cells.Virulence · 2012Review
- Mechanisms used by virulent Salmonella to impair dendritic cell function and evade adaptive immunity.Immunology · 2012Review
- IgG keeps virulent Salmonella from evading dendritic cell uptake.Immunology · 2012Article
- Analysis of interactions of Salmonella type three secretion mutants with 3-D intestinal epithelial cells.PloS one · 2010Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Salmonella enterica serovar Typhimurium can enter non-phagocytic cells, such as intestinal epithelial cells, by virtue of a Type Three Secretion System (TTSS) encoded in the Salmonella Pathogenicity Island 1 (SPI-1), which translocates bacterial effector molecules into the host cell. Salmonella can also be taken up by dendritic cells (DCs). Although the role of SPI-1 in non-phagocytic cell invasion is well established, its contribution to invasion of phagocytic cells has not been evaluated. Here, we have tested the invasive capacity of a S. Typhimurium strain lacking a key component of its TTSS-1 (DeltaInvC) leading to defective translocation of SPI-1-encoded effectors. Whereas this mutant Salmonella strain was impaired for invasion of non-phagocytic cells, it was taken up by DCs at a significantly higher rate than wild-type Salmonella. Similar to wild-type Salmonella, the DeltaInvC mutant strain retained the capacity to avoid antigen presentation to T cells. However, mice infected with the DeltaInvC mutant strain showed higher survival rate and reduced organ colonization. Our data suggest that, besides promoting phagocytosis by non-phagocytic cells, SPI-1 modulates the number of bacteria that enters DCs. The SPI-1 could be considered not only as an inducer of epithelial cell invasion but as a controller of DC entry.
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