ArticleAlcoholism, clinical and experimental research2010
MAOA alters the effects of heavy drinking and childhood physical abuse on risk for severe impulsive acts of violence among alcoholic violent offenders.
Article in Alcoholism, clinical and experimental research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Genetic Variants Associated With Resilience in Human and Animal Studies.Frontiers in psychiatry · 2022Pooled it
- MAOA, childhood maltreatment, and antisocial behavior: meta-analysis of a gene-environment interaction.Biological psychiatry · 2014Pooled it
- Reward Deficiency Syndrome (RDS): A Common Neurogenetic Trait/State of All Addictions: Is this the new DSM?British journal of healthcare and medical research · 2026Article
- The regulatory role of AP-2β in monoaminergic neurotransmitter systems: insights on its signalling pathway, linked disorders and theragnostic potential.Cell & bioscience · 2022Review
- Crime-Specific Recidivism in Criminal Justice Clients with Substance Use-A Cohort Study.International journal of environmental research and public health · 2022Article
- Reward Deficiency Syndrome (RDS): A Cytoarchitectural Common Neurobiological Trait of All Addictions.International journal of environmental research and public health · 2021Article
- The role of monoamine oxidase A in the neurobiology of aggressive, antisocial, and violent behavior: A tale of mice and men.Progress in neurobiology · 2020Review
- Forensic psychiatry in Finland: an overview of past, present and future.International journal of mental health systems · 2020Review
- MAOA variants differ in oscillatory EEG & ECG activities in response to aggression-inducing stimuli.Scientific reports · 2019Article
- Association of MAOA genetic variants and resilience with psychosocial stress: A longitudinal study of Syrian refugees.PloS one · 2019Article
- Violence exposure in an urban city: A GxE interaction with aggressive and impulsive behaviors.Journal of child psychology and psychiatry, and allied disciplines · 2019Article
- Introducing Precision Addiction Management of Reward Deficiency Syndrome, the Construct That Underpins All Addictive Behaviors.Frontiers in psychiatry · 2018Article
- Comorbidity of Alcohol Use Disorder and Chronic Pain: Genetic Influences on Brain Reward and Stress Systems.Alcoholism, clinical and experimental research · 2017Review
- Does MAOA increase susceptibility to prenatal stress in young children?Neurotoxicology and teratology · 2017Article
- Monoamine Oxidase A in Antisocial Personality Disorder and Borderline Personality Disorder.Current behavioral neuroscience reports · 2017Review
- MAOA expression predicts vulnerability for alcohol use.Molecular psychiatry · 2016Article
- Happiness & Health: The Biological Factors- Systematic Review Article.Iranian journal of public health · 2014Article
- The interactive effect of MAOA-LPR genotype and childhood physical neglect on aggressive behaviors in Italian male prisoners.Genes, brain, and behavior · 2014Article
- The MAOA gene predicts happiness in women.Progress in neuro-psychopharmacology & biological psychiatry · 2013Article
- The genetic basis of addictive disorders.The Psychiatric clinics of North America · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundA polymorphism in the promoter region of the monoamine oxidase A gene (MAOA) has been shown to alter the effect of persistent drinking and childhood maltreatment on the risk for violent and antisocial behaviors. These findings indicate that MAOA could contribute to inter-individual differences in stress resiliency.
methodsRecidivism in severe violent crimes was assessed after 8 years of nonincarcerated follow-up in a male sample of 174 impulsive Finnish alcoholic violent offenders, the majority of whom exhibited antisocial (ASPD) or borderline personality disorder (BPD) or both. We examined whether MAOA genotype alters the effects of heavy drinking and childhood physical abuse (CPA) on the risk for committing impulsive recidivistic violent crimes.
resultsLogistic regression analyses showed that both heavy drinking and CPA were significant independent predictors of recidivism in violent behavior (OR 5.2, p = 0.004 and OR 5.3, p = 0.003) among offenders having the high MAOA activity genotype (MAOA-H), but these predictors showed no effect among offenders carrying the low MAOA activity genotype (MAOA-L).
conclusionCarriers of the MAOA-H allele have a high risk to commit severe recidivistic impulsive violent crimes after exposure to heavy drinking and CPA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.