ArticleAlcoholism, clinical and experimental research2010
Ethanol enhances the interaction of breast cancer cells over-expressing ErbB2 with fibronectin.
Article in Alcoholism, clinical and experimental research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Integrated Network and Transcriptomic Analyses Identify a Candidate Ethanol-ADAM17 Molecular Axis Associated with Glioblastoma Progression.International journal of molecular sciences · 2026Article
- Early-onset cancer and modifiable risk: quantifying the combined impact of excess body weight and alcohol on breast and colorectal cancer in Italy (18-34 years).BMC public health · 2026Article
- Toxic and Nutritional Optic Neuropathies-An Updated Mini-Review.International journal of environmental research and public health · 2022Review
- Bioinformatics analysis identifies hub genes and pathways in nasopharyngeal carcinoma.Oncology letters · 2019Article
- Role of p38γ MAPK in regulation of EMT and cancer stem cells.Biochimica et biophysica acta. Molecular basis of disease · 2018Article
- Alcohol consumption promotes colorectal carcinoma metastasis via a CCL5-induced and AMPK-pathway-mediated activation of autophagy.Scientific reports · 2018Article
- Black rice-derived anthocyanins inhibit HER-2-positive breast cancer epithelial-mesenchymal transition-mediated metastasis in vitro by suppressing FAK signaling.International journal of molecular medicine · 2017Article
- Alcohol and Cancer Stem Cells.Cancers · 2017Review
- Cellular and molecular mechanisms underlying alcohol-induced aggressiveness of breast cancer.Pharmacological research · 2017Review
- Distinct ErbB2 receptor populations differentially interact with beta1 integrin in breast cancer cell models.PloS one · 2017Article
- ErbB2 and p38γ MAPK mediate alcohol-induced increase in breast cancer stem cells and metastasis.Molecular cancer · 2016Article
- Role of MCP-1 in alcohol-induced aggressiveness of colorectal cancer cells.Molecular carcinogenesis · 2016Article
- Chronic ethanol exposure enhances the aggressiveness of breast cancer: the role of p38γ.Oncotarget · 2016Article
- Links between alcohol consumption and breast cancer: a look at the evidence.Women's health (London, England) · 2015Review
- ErbB/integrin signaling interactions in regulation of myocardial cell-cell and cell-matrix interactions.Biochimica et biophysica acta · 2013Review
- erbB expression changes in ethanol and 7,12- dimethylbenz (a)anthracene-induced oral carcinogenesis.Medicina oral, patologia oral y cirugia bucal · 2013Article
- Ethanol disrupts vascular endothelial barrier: implication in cancer metastasis.Toxicological sciences : an official journal of the Society of Toxicology · 2012Article
- Double-stranded RNA-dependent protein kinase regulates the motility of breast cancer cells.PloS one · 2012Article
- Moderate ethanol ingestion and cardiovascular protection: from epidemiologic associations to cellular mechanisms.Journal of molecular and cellular cardiology · 2012Review
- Cyanidin-3-glucoside inhibits ethanol-induced invasion of breast cancer cells overexpressing ErbB2.Molecular cancer · 2010Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundEthanol is a tumor promoter and may enhance the metastasis of breast cancer. However, the underlying cellular/molecular mechanisms remain unknown. Amplification of ErbB2 or HER2, a receptor tyrosine kinase of the ErbB family, is found in 20 to 30% of patients with breast cancer. We have previously demonstrated that the effect of ethanol on the migration/invasion of breast cancer cells positively correlated with the expression levels of ErbB2. Adhesion to the extracellular matrix (ECM) is an important initial step for cancer cell invasion and metastasis. In this study, we investigated the effects of ethanol on the adhesion of MCF7 breast cancer cells over-expressing ErbB2 (MCF7(ErbB2)) to human plasma fibronectin.
methodsTo test the hypothesis that ethanol may enhance the attachment of human breast cancer cells to fibronectin, an important component of the ECM, we evaluated the effect of ethanol on the expression of focal adhesions, cell attachment, and ErbB2 signaling in cultured MCF7(ErbB2) cells.
resultsExposure to ethanol drastically enhanced the adhesion of MCF(ErbB2) cells to fibronectin and increased the expression of focal adhesions. Ethanol induced phosphorylation of ErbB2 at Tyr1248, FAK at Tyr861, and cSrc at Try216. Ethanol promoted the interaction among ErbB2, FAK, and cSrc, and the formation of a focal complex. AG825, a selective ErbB2 inhibitor, attenuated the ethanol-induced phosphorylation of ErbB2 and its association with FAK. Furthermore, AG825 blocked ethanol-promoted cell/fibronectin adhesion as well as the expression of focal adhesions.
conclusionsOur results suggest that ethanol enhances the adhesion of breast cancer cells to fibronectin in an ErbB2-dependent manner, and the FAK pathway plays an important role in ethanol-induced formation of a focal complex.
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