Trial reportJournal of perinatology : official journal of the California Perinatal Association2010
Randomized trial of enteral protein and energy supplementation in infants less than or equal to 1250 g at birth.
Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 4 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- High protein intake on later outcomes in preterm children: a systematic review and meta-analysis.Pediatric research · 2025Pooled it
- Comparison of different protein concentrations of human milk fortifier for promoting growth and neurological development in preterm infants.The Cochrane database of systematic reviews · 2020Pooled it
- Higher versus lower protein intake in formula-fed low birth weight infants.The Cochrane database of systematic reviews · 2020Pooled it
- Higher versus lower protein intake in formula-fed low birth weight infants.The Cochrane database of systematic reviews · 2014Pooled it
- [Interpretation of key points from the "Expert Consensus on Diagnosis and Management of Neonatal Cow Milk Protein Allergy (2023)"].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Article
- Analysis of Amino Acid Patterns With Nutrition Regimens in Preterm Infants With Extrauterine Growth Retardation.Frontiers in pediatrics · 2020Article
- Protein Intake and Growth in Preterm Infants: A Systematic Review.Global pediatric health · 2014Review
- Aggressive Nutrition of the Preterm Infant.Current pediatrics reports · 2013Article
- Neurocritical care for neonates.Current treatment options in neurology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 6 institutions in 1 country.
Funding
Abstract
objectiveTo determine if enteral protein and energy supplementation would significantly improve weight gain as compared with energy supplementation alone in <or=1250 g infants. STUDY
designInclusion criteria were birth weight (BW) <or=1250 g, postnatal age >or=14 days, diet of >or=75% enteral nutrition (fortified human milk or formula) and either failure to regain BW or weight gain<15 g kg(-1) per days. Infants were randomized to a multinutrient supplement that provided increased protein and energy (P/E) intake or energy alone (medium chain triglyceride oil, MCT). Growth rates were compared at the end of the 4-week study period.
resultOf 30 eligible infants, 23 were enrolled, 12 received MCT (BW=862+/-252 g, mean+/-s.d.) and 11 received P/E (BW=879+/-241 g). Significantly higher protein intake (P/E=3.5+/-0.3 g kg(-1) per day, MCT=3.0+/-0.5 g kg(-1) per day) and better growth (P/E=17.0+/-2.4 g kg(-1) per day, MCT=11.5+/-4.8 g kg(-1) per day) were observed in the P/E group.
conclusionThese data are consistent with the importance of providing additional daily protein intake to achieve increased postnatal growth in very low birth weight infants experiencing slow growth.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.