ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2010
Is human papillomavirus viral load a clinically useful predictive marker? A longitudinal study.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Human papillomavirus testing versus repeat cytology for triage of minor cytological cervical lesions.The Cochrane database of systematic reviews · 2013Pooled it
- Negative Xpert HPV Test (Cepheid) With Late Amplification Signals: Is There a Clinical Significance? (the PaPCR Study).Journal of medical virology · 2026Article
- Correlation of different HPV genotype viral loads and cervical lesions: A retrospective analysis of 1585 cases.Cancer cytopathology · 2025Article
- Nonlinear relationship between viral load and TCT in single/multiple HPV52 infection.Virology journal · 2024Article
- Correlation between human papillomavirus viral load and cervical lesions classification: A review of current research.Frontiers in medicine · 2023Review
- Changes in the Cervical Microbiota of Women with Different High-Risk Human Papillomavirus Loads.Viruses · 2022Article
- Significance of the viral load of high-risk HPV in the diagnosis and prediction of cervical lesions: a retrospective study.BMC women's health · 2021Article
- Prevalence of Human Papillomavirus (HPV) Genotypes in Cervicovaginal Secretions of Human Immunodeficiency Virus (HIV) Positive Indian Women and Correlation With Clinico-Virological Parameters.Frontiers in reproductive health · 2021Article
- HR-HPV viral load quality detection provide more accurate prediction for residual lesions after treatment: a prospective cohort study in patients with high-grade squamous lesions or worse.Medical oncology (Northwood, London, England) · 2020Article
- Article
- HPV viral load in self-collected vaginal fluid samples as predictor for presence of cervical intraepithelial neoplasia.Virology journal · 2019Article
- Defining the frequency of human papillomavirus and polyomavirus infection in urothelial bladder tumours.Scientific reports · 2018Article
- Prevalence of the integration status for human papillomavirus 16 in esophageal carcinoma samples.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2018Article
- Type-specific high-risk human papillomavirus viral load as a viable triage indicator for high-grade squamous intraepithelial lesion: a nested case- control study.Cancer management and research · 2018Article
- Analysis of human papilloma virus type 52 integration status in exfoliated cervical cells.Experimental and therapeutic medicine · 2017Article
- Digital droplet PCR (ddPCR) for the detection and quantification of HPV 16, 18, 33 and 45 - a short report.Cellular oncology (Dordrecht, Netherlands) · 2017Article
- Type-dependent association between risk of cervical intraepithelial neoplasia and viral load of oncogenic human papillomavirus types other than types 16 and 18.International journal of cancer · 2017Article
- Long-Term Follow-up of HPV Infection Using Urine and Cervical Quantitative HPV DNA Testing.International journal of molecular sciences · 2016Article
- Viral load and short-term natural history of type-specific oncogenic human papillomavirus infections in a high-risk cohort of midadult women.International journal of cancer · 2014Article
- Viral load, integration and methylation of E2BS3 and 4 in human papilloma virus (HPV) 16-positive vaginal and vulvar carcinomas.PloS one · 2014Article
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6 authors.
Funding
Abstract
backgroundIt has been suggested that in women who test positive for high-risk human papillomavirus (HPV) types, viral load can distinguish women who are at increased risk of cervical neoplasia from those who are not.
methodsQuantitative PCR (qPCR) was used to measure HPV copy number in serial samples taken from 60 and 58 young women previously found to have incident cervical HPV16 or HPV18 infections, respectively, using GP5+/GP6+ primers; women provided at least three samples for qPCR testing, at least one of which was positive.
resultsA 10-fold increase in HPV16 or HPV18 copy number was associated with a modestly increased risk of acquiring a cytologic abnormality [HPV16: hazards ratio, 1.76 (95% confidence interval, 1.38-2.25); HPV18: hazards ratio, 1.59 (95% confidence interval, 1.25-2.03)]. However, in most women, copy number increased during follow-up, before decreasing again. In women with a HPV16 infection, the median copy number per 1,000 cells was 7.7 in their first qPCR HPV-positive sample, 1,237 in the sample yielding the maximum copy number, and 7.8 in their last qPCR HPV-positive sample; corresponding copy numbers for women with HPV18 infection were 2.3, 87, and 2.4. Maximum HPV16 and HPV18 copy number did not differ significantly between women who acquired an incident cervical cytologic abnormality and those who did not.
conclusionWhereas large relative increases in copy number are associated with an increased risk of abnormality, a single measurement of viral load made at an indeterminate point during the natural history of HPV infection does not reliably predict the risk of acquiring cervical neoplasia. Therefore, a single measure of HPV viral load cannot be considered a clinically useful biomarker.
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