ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2010
A segregation analysis of Barrett's esophagus and associated adenocarcinomas.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review with meta-analysis: the effects of family history on the risk of Barrett's oesophagus and oesophageal adenocarcinoma.Alimentary pharmacology & therapeutics · 2021Pooled it
- Variation in age at cancer diagnosis in familial versus nonfamilial Barrett's esophagus.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2012Trial
- VSIG10L is a major determinant of esophageal homeostasis and inherited predisposition to Barrett's esophagus.Nature communications · 2026Article
- Age of diagnosis in familial Barrett's associated neoplasia.Familial cancer · 2022Article
- Germline variant in MSX1 identified in a Dutch family with clustering of Barrett's esophagus and esophageal adenocarcinoma.Familial cancer · 2018Article
- Association of sporadic and familial Barrett's esophagus with breast cancer.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2018Article
- The Evolving Genomic Landscape of Barrett's Esophagus and Esophageal Adenocarcinoma.Gastroenterology · 2017Review
- Complex Segregation Analysis Provides Evidence for Autosomal Dominant Transmission in the Chinese Han Families with Ankylosing Spondylitis.BioMed research international · 2017Article
- Association Between Germline Mutation in VSIG10L and Familial Barrett Neoplasia.JAMA oncology · 2016Article
- Linkage and related analyses of Barrett's esophagus and its associated adenocarcinomas.Molecular genetics & genomic medicine · 2016Article
- The Genetics of Barrett's Esophagus: A Familial and Population-Based Perspective.Digestive diseases and sciences · 2016Review
- Predictors of Progression to High-Grade Dysplasia or Adenocarcinoma in Barrett's Esophagus.Gastroenterology clinics of North America · 2015Review
- Barrett's oesophagus: frequency and prediction of dysplasia and cancer.Best practice & research. Clinical gastroenterology · 2015Review
- Hereditary Factors in Esophageal Adenocarcinoma.Gastrointestinal tumors · 2014Review
- Review
- Segregation analysis of mandibular prognathism in Korean orthognathic surgery patients and their families.The Angle orthodontist · 2013Article
- Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus.Nature genetics · 2012Article
- Diagnosis and management of Barrett's esophagus.The Surgical clinics of North America · 2012Review
- Hereditary gastrointestinal cancer syndromes.Gastrointestinal cancer research : GCR · 2011Article
- Comparison of endoscopic and clinical characteristics of patients with familial and sporadic Barrett's esophagus.Digestive diseases and sciences · 2011Article
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11 authors.
Funding
Abstract
Familial aggregation of esophageal adenocarcinomas, esophagogastric junction adenocarcinomas, and their precursor Barrett's esophagus (BE) has been termed familial BE (FBE). Numerous studies documenting increased familial risk for these diseases raise the hypothesis that there may be an inherited susceptibility to the development of BE and its associated cancers. In this study, using segregation analysis for a binary trait as implemented in S.A.G.E. 6.0.1, we analyzed data on 881 singly ascertained pedigrees to determine whether FBE is caused by a common environmental or genetic agent and, if genetic, to identify the mode of inheritance of FBE. The inheritance models were compared by likelihood ratio tests and Akaike's A Information Criterion. Results indicated that random environmental and/or multifactorial components were insufficient to fully explain the familial nature of FBE, but rather, there is segregation of a major type transmitted from one generation to the next (P < 10(-10)). An incompletely dominant inheritance model together with a polygenic component fits the data best. For this dominant model, the estimated penetrance of the dominant allele is 0.1005 [95% confidence interval (95% CI), 0.0587-0.1667] and the sporadic rate is 0.0012 (95% CI, 0.0004-0.0042), corresponding to a relative risk of 82.53 (95% CI, 28.70-237.35) or odds ratio of 91.63 (95% CI, 32.01-262.29). This segregation analysis provides epidemiologic evidence in support of one or more rare autosomally inherited dominant susceptibility allele(s) in FBE families and, hence, motivates linkage analyses.
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